Results 91 to 100 of about 308,193 (309)

Predictive Capacity of Risk Models in Liver Transplantation

Transplantation Direct, 2019
Background. Several risk models to predict outcome after liver transplantation (LT) have been developed in the last decade. This study compares the predictive performance of 7 risk models. Methods.
Jacob D. de Boer, MD, Hein Putter, PhD, Joris J. Blok, MD, PhD, Ian P.J. Alwayn, MD, PhD, Bart van Hoek, MD, PhD, Andries E. Braat, MD, PhD   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation [PDF]

, 2000
Background. In this report, we compare the long-term outcome of pediatric liver transplantation (LTx) patients maintained with tacrolimus-based and with cyclosporine (CsA)-based immunosuppressive therapy.
Fung, J, Green, M, Gronsky, C, Jain, A, Kashyap, R, Mazariegos, G, Reyes, J, Starzl, TE   +7 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Donor-specific antibodies require preactivated immune system to harm renal transplant

EBioMedicine, 2016
Background: It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from
Caner Süsal, Bernd Döhler, Andrea Ruhenstroth, Christian Morath, Antonij Slavcev, Thomas Fehr, Eric Wagner, Bernd Krüger, Margaret Rees, Sanja Balen, Stela Živčić-Ćosić, Douglas J. Norman, Dirk Kuypers, Marie-Paule Emonds, Przemyslaw Pisarski, Claudia Bösmüller, Rolf Weimer, Joannis Mytilineos, Sabine Scherer, Thuong H. Tran, Petra Gombos, Peter Schemmer, Martin Zeier, Gerhard Opelz   +23 more
doaj   +1 more source

Prognostic factors for renal transplant graft survival in a retrospective cohort of 1000 cases: The role of desensitization therapy

Journal of the Formosan Medical Association, 2020
Background: To review the results of renal transplantation after promulgation of the Human Organ Transplant Act in Taiwan in 1987, we conducted a retrospective study in the first 1000 cases performed in our hospital. Prognostic factors for graft survival
Chih-Yuan Lee, Ching-Yao Yang, Wei-Chou Lin, Chien-Chia Chen, Meng-Kun Tsai   +4 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Effect of urinary tract infection on the outcome of the allograft in patients with kidney transplantation [PDF]

Brazilian Journal of Nephrology
Background: Urinary tract infections (UTIs) are the second most common cause of graft dysfunction, accounting for significant morbidity, and are associated with poor graft and patient survival.
Rahul Sai Gangula, Mahesh Eshwarappa, R Rajashekar, Hamsa Reddy, Pooja Prakash Prabhu, Gireesh M Siddaiah, Gurudev Konana Chennabasappa, Lia Sara Anish, Yousuff Mohammad   +8 more
doaj   +1 more source

Impact of Combinations of Donor and Recipient Ages and Other Factors on Kidney Graft Outcomes

Frontiers in Immunology, 2020
As the availability of kidneys for transplantation continues to be outpaced by its growing demand, there has been an increasing utilization of older deceased donors in the last decades. Considering that definition of factors that influence deceased donor
Maria Gerbase-DeLima, Renato de Marco, Franscisco Monteiro, Hélio Tedesco-Silva, José O. Medina-Pestana, José O. Medina-Pestana, Karina L. Mine   +6 more
doaj   +1 more source

Long-term results of cyclosporine-steroid therapy in 131 non-matched cadaveric renal transplants. [PDF]

, 1987
One-hundred-and-twenty-eight recipients of 131 consecutive, non-matched cadaver renal allografts were treated with cyclosporine and steroids. They have been followed for 4 to 6 yr.
Carpenter, Barbara J, Gordon, Robert D, Hakala, Thomas R, Iwatsuki, Shunzaburo, Rosenthal, J Thomas, Schroter, Gerhard PJ, Starzl, Thomas E, Taylor, Rodney J, Well, Richard   +8 more
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