Results 71 to 80 of about 168,165 (319)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Dynamic predictions of kidney graft survival in the presence of longitudinal outliers [PDF]

arXiv, 2019
Dynamic predictions of survival outcomes are of great interest to physicians and patients, since such predictions are useful elements of clinical decision-making. Joint modelling of longitudinal and survival data has been increasingly used to obtain dynamic predictions.
arxiv  

Establishment and biological characterization of radioresistant colorectal cancer cell lines

FEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu, Qing Dai, Jing Leng, Lin Fang, Jing‐Jing Ma, Rui Chen, Che Chen, Peng‐Fei Ran, Wen‐Wen Zhou, Chang Liu, Huang‐Fei Yu   +10 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Donor-specific antibodies require preactivated immune system to harm renal transplant

EBioMedicine, 2016
Background: It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from
Caner Süsal, Bernd Döhler, Andrea Ruhenstroth, Christian Morath, Antonij Slavcev, Thomas Fehr, Eric Wagner, Bernd Krüger, Margaret Rees, Sanja Balen, Stela Živčić-Ćosić, Douglas J. Norman, Dirk Kuypers, Marie-Paule Emonds, Przemyslaw Pisarski, Claudia Bösmüller, Rolf Weimer, Joannis Mytilineos, Sabine Scherer, Thuong H. Tran, Petra Gombos, Peter Schemmer, Martin Zeier, Gerhard Opelz   +23 more
doaj   +1 more source

Results of the kidney transplant programme at the University Clinical Centre of the Republic of Srpska from 2010 to 2018 [PDF]

Scripta Medica, 2019
Background: Kidney transplantation is the best treatment for patients with end-stage renal disease (ESRD). The aim of the study was to show the results of kidney transplantation performed in the University Clinical Centre of the Republic of Srpska in the
Grujičić Milorad, Žigić Milan, Maksić Milanko, Hajder Slobodan, Golić Darko, Gašić Branislav, Rakanović Dragan, Vasić Novak, Laganin Nataša, Roljić Zoran, Stajčić Ljubomir, Mišković Mirjana, Mićić-Zrnić Dubravka, Topić Goran, Đajić Vlado   +14 more
doaj  

Effect of urinary tract infection on the outcome of the allograft in patients with kidney transplantation [PDF]

Brazilian Journal of Nephrology
Background: Urinary tract infections (UTIs) are the second most common cause of graft dysfunction, accounting for significant morbidity, and are associated with poor graft and patient survival.
Rahul Sai Gangula, Mahesh Eshwarappa, R Rajashekar, Hamsa Reddy, Pooja Prakash Prabhu, Gireesh M Siddaiah, Gurudev Konana Chennabasappa, Lia Sara Anish, Yousuff Mohammad   +8 more
doaj   +1 more source

Deep Learning Approach for Predicting 30 Day Readmissions after Coronary Artery Bypass Graft Surgery [PDF]

arXiv, 2018
Hospital Readmissions within 30 days after discharge following Coronary Artery Bypass Graft (CABG) Surgery are substantial contributors to healthcare costs. Many predictive models were developed to identify risk factors for readmissions. However, majority of the existing models use statistical analysis techniques with data available at discharge.
arxiv  

Prolonged Allogeneic Islet Graft Survival by Protoporphyrins

Cell Transplantation, 2005
Transplantation of islets of Langerhans in patients with type 1 diabetes allows for improved metabolic control and insulin independence. The need for chronic immunosuppression limits this procedure to selected patients with brittle diabetes.
Pileggi, Antonello, Molano, R Damaris, Berney, Thierry, Ichii, Hirohito, San Jose, Sergio, Zahr, Elsie, Poggioli, Raffaella, Linetsky, Elina, Ricordi, Camillo, Inverardi, Luca   +9 more
openaire   +5 more sources

7 Years Experience of Living Donor Kidney Transplantation in Indonesia: A Retrospective Cohort Study

Acta Medica Indonesiana, 2018
Background: kidney transplantation has been developing rapidly in Indonesia in recent years, yet data on transplants’ characteristics and survival is still unavailable. In Indonesia, only living donors are permitted.
Maruhum Bonar H Marbun, Endang Susalit, Vidhia Umami   +2 more
doaj