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Acute graft versus host disease [PDF]
Orphanet Journal of Rare Diseases, 2007 Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins
Vogelsang Georgia B, Jacobsohn David A
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NOTCH and Graft-Versus-Host Disease [PDF]
Frontiers in Immunology, 2018 In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD).
Mauro Di Ianni +15 more
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Human Graft Versus Host Disease
Journal of Investigative Dermatology, 1980 Human graft versus host disease is composed of 2 distinct clinical entities, acute graft versus host disease and chronic graft versus host disease, which have different pathogenesis. Acute graft versus host disease is produced by the attack of donor immunocompetent T or null lymphocytes against recipient histocompatibility antigens.
Robertson Parkman +2 more
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Transplantation, 1968 Graft-versus-host disease was induced in adult hybrid rats by injection of spleen cells from either or both parental strains. Under the conditions of these experiments, GVH disease infiltrates appeared in the hepatic portal areas in all rats splenectomized before injection, but rarely in intact or sham-operated animals.
Seymour Levine
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Graft-versus-host disease [PDF]
Case Reports, 2010 This article presents the case of a 26-year-old man who was diagnosed with pneumatosis cystoides intestinalis, a rare consequence of colonic graft-versus-host disease, after CT imaging revealed free air tracking within the bowel wall and abdomen. His presentation with hiccups, abdominal and neck distension, along with diarrhoea was also unusual, and ...
Satyajit Sahu +4 more
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Ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in a pediatric population [PDF]
Hematology, Transfusion and Cell TherapyAim: To determine the prevalence of ocular graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and to characterize the risk factors associated with its development in a pediatric population.
Cinthia Kim +5 more
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PLoS ONE, 2021 Graft-versus-host disease is a major complication after allogeneic hematopoietic stem cell transplantation for hematological malignancies. Immunosuppressive drugs, such as anti-thymocyte globulin, alemtuzumab, and post-transplant cyclophosphamide, have ...
Kiyomi Mashima +17 more
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Graft-Versus-Host Disease: A Review [PDF]
Journal of the Royal Society of Medicine, 1987 A. John Barrett
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Hematology/Oncology Clinics of North America, 1990 Graft-versus-host disease (GVHD) is caused by immunologic recognition of the patient by the donor marrow graft after allogeneic bone marrow transplantation. Despite advances in understanding and new agents and methods to treat GVHD, the disease and complications related to it and its treatment are the principal causes of death after transplantation ...
Georgia B. Vogelsang, John E. Wagner
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Graft-versus-host disease [PDF]
The Lancet, 2009 Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk haematological malignant disorders and other life-threatening haematological and genetic diseases. The main complication of HCT is graft-versus-host disease (GVHD), an immunological disorder that affects many organ systems, including the gastrointestinal tract ...
Ernst Holler +3 more
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