Results 141 to 150 of about 234,176 (365)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Enfermedad injerto contra huesped: sus manifestaciones bucales

Revista Cubana de Estomatología
La enfermedad injerto contra huésped es la principal complicación que sufren los pacientes que han recibido trasplante alogénico. Se produce como consecuencia de una reacción inflamatoria exagerada mediada por los linfocitos del donante y estimulada por ...
Claudia Marcela Hernández Cancino, Renata Córdova Petersen, Isabel Nemoto Vergara Sasada, Caroline Siviero Dillenburg, Ingeburg Hellwig   +4 more
doaj  

Establishment of early donor engraftment after reduced-intensity allogeneic hematopoietic stem cell transplantation to potentiate the graft-versus-lymphoma effect against refractory lymphomas [PDF]

, 2003
Reduced-intensity allogeneic hematopoietic stem cell transplantation (alloHSCT), which typically results in mixed chimerism initially after transplantation, has had limited efficacy in chemotherapy-refractory lymphomas.
Bishop, Michael R., Castro, Kathleen, Fowler, Daniel H., Gea-Banacloche, Juan, Gress, Ronald, Hou, Jeannie Whit-Shan, Kasten-Sportes, Claude, Marchigiani, Donna, Odom, Jeanne, Steinberg, Seth M., Wilson, Wyndham H.   +10 more
core   +1 more source

An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP

Advanced Science, EarlyView.
The salivary sheath protein myosin from SBPH is critical for the formation of the salivary sheath and feeding. However, myosin functions as a HAMP and triggered plant BAK1‐mediated PTI responses, which include the activation of calcium signaling pathways, MAPK phosphorylation, ROS bursts, and cell death, thereby triggering JA pathway.
Liangxuan Qi, Jing Li, Shuai Li, Jing Li, Han Wang, Lei Yang, Xinyang Tan, Zhichang Zhao, Guanghua Luo, Maofeng Jing, Ary A. Hoffmann, Jichao Fang, Rui Ji   +12 more
wiley   +1 more source

The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation

Haematologica, 2012
Background We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion of T cells with suppressive properties.
Teresa Caballero-Velázquez, Luis Ignacio Sánchez-Abarca, Silvia Gutierrez-Cosio, Belén Blanco, Cristina Calderon, Carmen Herrero, Soraya Carrancio, Concepción Serrano, Consuelo del Cañizo, Jesús F. San Miguel, José A. Pérez-Simón   +10 more
doaj   +1 more source

Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research [PDF]

, 2016
The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules.
Abdel-Azim, H, Arora, M, Askar, M, Bitan, M, Dandoy, C, Drobyski, W, Fernandez-Viña, MA, Gandhi, M, Hale, G, Horowitz, MM, Lazaryan, A, Lee, SJ, Marsh, SG, Müller, CR, Nishihori, T, Olsson, R, Oudshoorn, M, Page, K, Pidala, J, Reshef, R, Savani, B, Schultz, K, Spellman, SR, Verneris, MR, Wang, HL, Wang, T, Weisdorf, DJ, Yong, A   +27 more
core   +4 more sources

Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

Advanced Science, EarlyView.
Low reproducibility and inefficient gene transfer hamper clinical manufacturing of chimeric antigen receptor regulatory T cells (CAR Tregs). Nanoneedle mediated electroporation generates primary human CAR Tregs under good manufacturing practice conditions with superior efficiency compared to viral transduction.
Ningjia Sun, Cong Wang, William Edwards, Yikai Wang, Xiangrong L. Lu, Chenlei Gu, Samuel McLennan, Panicos Shangaris, Peng Qi, Daniela Mastronicola, Cristiano Scottà, Giovanna Lombardi, Ciro Chiappini   +12 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids

Haematologica, 2011
Background Advances in acute graft-versus-host disease therapy are needed.Design and Methods We examined the efficacy of sirolimus as primary therapy for acute graft-versus-host disease in 32 patients.Results Acute graft-versus-host disease involved the ...
Joseph Pidala, Marcie Tomblyn, Taiga Nishihori, Teresa Field, Ernesto Ayala, Janelle Perkins, Hugo Fernandez, Fred Locke, Lia Perez, Jose Leonel Ochoa, Melissa Alsina, Claudio Anasetti   +11 more
doaj   +1 more source

Potential Mechanisms of Photopheresis in Hematopoietic Stem Cell Transplantation [PDF]

, 2006
Immune tolerance describes specific unresponsiveness to antigens. In clinical situations such as graft-versus-host disease it may be useful to capitalize on these pre-existing tolerance mechanisms to treat patients.
Peritt, David
core   +1 more source