Results 161 to 170 of about 234,176 (365)

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

Transplantation of allogeneic bone marrow without graft-versus-host disease using total lymphoid irradiation. [PDF]

, 1978
S Slavin, Zvi Fuks, Hillard Kaplan, Samuel Strober   +3 more
openalex   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

Advanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez Alfonso, Rayhane Nchioua, Pascal von Maltitz, Dan Pascal Jean Albers, Fabian Zech, Julie Vandeput, Lieve Naesens, Giorgio Fois, Veronika Neubauer, Nico Preising, Emilia Schmierer, Yasser Almeida‐Hernandez, Moritz Petersen, Ludger Ständker, Sebastian Wiese, Peter Braubach, Manfred Frick, Eberhard Barth, Daniel Sauter, Frank Kirchhoff, Elsa Sanchez‐Garcia, Annelies Stevaert, Jan Münch   +24 more
wiley   +1 more source

Treatment of Established Human Graft-Versus-Host Disease by Antithymocyte Globulin [PDF]

, 1974
Rainer Storb, Éliane Gluckman, E. Donnall Thomas, CD Buckner, R. A. Cliff, A Fefer, Harold Glucksberg, T. C. Graham, F L Johnson, K. G. Lerner, P Neiman, Hans D. Ochs   +11 more
openalex   +1 more source

A severity‐based tumor‐superior mesenteric/portal vein interface grading criteria as a predictor of survival outcomes in pancreatic head ductal adenocarcinoma patients undergoing pancreaticoduodenectomy following neoadjuvant chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
PDAC patients with the radiological severe interface (≥25 contact length and ≥210 degrees circumferential tumor‐SMV/PV interface) may help predict poor survival outcomes preoperatively. Abstract Aim To assess the ability of a new severity‐based tumor‐superior mesenteric/portal vein interface criteria to predict survival outcomes in pancreatic ductal ...
Benson Kaluba, Naohisa Kuriyama, Motonori Nagata, Takahiro Ito, Aoi Hayasaki, Takehiro Fujii, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Shugo Mizuno   +9 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

The role of graft T-cell size in patients receiving alemtuzumab serotherapy for non-malignant disorders: results of an institutional protocol

Scientific Reports
Although graft T cells assist in engraftment, mediate antiviral immune-reconstitution, and cause graft-versus-host disease, graft size is not determined by T-cell content of the graft.
Ambreen Pandrowala, Sanna Khan, Darshan Kataria, Manasa Kakunje, Varsha Mishra, Dhruv Mamtora, Sangeeta Mudaliar, Minnie Bodhanwala, Bharat Agarwal, Prashant Hiwarkar   +9 more
doaj   +1 more source

ANALYSIS OF GRAFT-VERSUS-HOST DISEASE IN SYRIAN HAMSTERS [PDF]

, 1972
J. Wayne Streilein
openalex   +1 more source

Promoting radical healing to facilitate community capacity building among formerly incarcerated Black and Latino men with substance use disorders

American Journal of Community Psychology, EarlyView.
Abstract This study reports on a qualitative thematic analysis of secondary data from group session recordings collected as part of the Community Wise Optimization Trial. Community Wise is a multilevel behavioral intervention designed to increase critical consciousness and reduce substance use among formerly incarcerated men living in predominantly ...
Richmond E. Hayes, Heather A. Jones, Ellen Benoit, Dora N. Watkins, Liliane C. Windsor   +4 more
wiley   +1 more source

Acute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 100, Issue 5, Page 860-891, May 2025.
ABSTRACT Disease Overview Acute myeloid leukemia (AML) is a bone marrow stem cell cancer that is often fatal despite available treatments. Diagnosis, risk assessment, monitoring, and therapeutic management of AML have changed dramatically in the last decade due to increased pathophysiologic understanding, improved assessment technology, and the ...
Shai Shimony, Maximilian Stahl, Richard M. Stone   +2 more
wiley   +1 more source