Results 71 to 80 of about 234,176 (365)

Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells

Haematologica, 2013
Despite advances in immunosuppressive regimens, acute graft-versus-host disease remains a frequent complication of allogeneic hematopoietic cell transplantation.
Anne-Kathrin Hechinger, Kristina Maas, Christoph Dürr, Franziska Leonhardt, Gabriele Prinz, Reinhard Marks, Ulrike Gerlach, Maike Hofmann, Paul Fisch, Jürgen Finke, Hanspeter Pircher, Robert Zeiser   +11 more
doaj   +1 more source

Biofilm Control by Active Topography with Mucin Coating

Advanced Functional Materials, EarlyView.
This study reports a new antifouling strategy based on a bioinspired design. Mucin coating enhances biofilm control by active topography with beating micron‐sized pillars. Besides the mechanical force of beating pillars, the antibiofilm activities also involve biological factors since mucin coating inhibits swarming motility and c‐di‐GMP synthesis in ...
Zehui Han, Yikang Xu, Huan Gu, Teng Zhang, Dacheng Ren   +4 more
wiley   +1 more source

Interleukin-10 spot-forming cells as a novel biomarker of chronic graft-versus-host disease

Haematologica, 2013
Although there are National Institutes of Health consensus criteria for the global assessment of chronic graft-versus-host disease, no validated biomarkers have been established for this disease.
Masahiro Hirayama, Eiichi Azuma, Atsuko Nakagawa-Nakazawa, Tadashi Kumamoto, Shotaro Iwamoto, Keishiro Amano, Shigehisa Tamaki, Eiji Usui, Yoshihiro Komada   +8 more
doaj   +1 more source

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation [PDF]

, 2010
Heparanase, endoglycosidase that cleaves heparan sulfate side chains of heparan sulfate proteoglycans, plays important roles in cancer metastasis, angiogenesis and inflammation.Applying a mouse model of bone marrow transplantation and transgenic mice ...
Arnon Nagler, Derya Unutmaz, Eyal Zcharia, Israel Vlodavsky, Lola Weiss, Menachem Bitan, Michael Zeira, Shimon Slavin   +7 more
core   +3 more sources

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

Advanced Functional Materials, EarlyView.
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen, Andreas B. Pedersen, Mireia Casanovas Montasell, Søren Moesgaard, Anja Bille Bohn, Alexander N. Zelikin   +5 more
wiley   +1 more source

Membranous nephropathy and lupus-like syndrome after hematopoietic cell transplantation: a case report [PDF]

, 2010
Introduction The kidney is increasingly recognised as a target organ of chronic graft-versus-host disease after hematopoietic cell transplantation in the context of the development of the nephrotic syndrome.
A Chang, A Tyndall, Constantina Petraki, Dimitris Xydakis, Eleftheria Vardaki, Eugene Daphnis, GS Chan, Ioannis Petrakis, Irene Xylouri, J Lin, JH Lee, K Brukamp, Kostas Perakis, Kostas Stylianou, M Higman, Michael Alexandrakis, ML Troxell, P Reddy, Peggy Kanellou, PS Rao, R Srinivasan, Spyros Stratigis, Stavros Stratakis, Theodora Katsarou, Vasiliki Mavroeidi   +24 more
core   +3 more sources

Polymer Brushes in Cylindrical Pores: Simulation versus Scaling Theory [PDF]

, 2006
The structure of flexible polymers endgrafted in cylindrical pores of diameter D is studied as a function of chain length N and grafting density \sigma, assuming good solvent conditions. A phenomenological scaling theory, describing the variation of the linear dimensions of the chains with \sigma, is developed and tested by Molecular Dynamics ...
arxiv   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Development of a platform consisting of 3D microscaffolds supporting 3D embryoid bodies for neuronal research. The polymeric scaffolds enable directed growth of neurites. This study shows nanodiamond‐based quantum sensors graft onto the polymer material, enabling quantum metrology experiments within the 3D neuronal model and thereby providing a ...
Beatriz N. L. Costa, Ana Marote, Catarina Barbosa, Jonas Campos, António J. Salgado, Jana B. Nieder   +5 more
wiley   +1 more source

Locally self-organized quasi-critical percolation in a multiple disease model [PDF]

Phys. Rev. E 84, 036119 (2011), 2011
Diseases emerge, persist and vanish in an ongoing battle for available hosts. Hosts, on the other hand, defend themselves by developing immunity that limits the ability of pathogens to reinfect them. We here explore a multi-disease system with emphasis on mutual exclusion.
arxiv   +1 more source