Results 81 to 90 of about 234,176 (365)

Fairly Predicting Graft Failure in Liver Transplant for Organ Assigning [PDF]

arXiv, 2023
Liver transplant is an essential therapy performed for severe liver diseases. The fact of scarce liver resources makes the organ assigning crucial. Model for End-stage Liver Disease (MELD) score is a widely adopted criterion when making organ distribution decisions. However, it ignores post-transplant outcomes and organ/donor features.
arxiv  

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

Ocular Graft versus Host Disease

Vision Pan-America, 2015
Allogeneic hematopoietic stem cell transplantation is considered the standard of care for hematological and lymphoid malignancies. One of the complications associated to this therapy is an immune-mediated reaction known as graft versus host disease with ...
Paulo E.C. Dantas
doaj   +1 more source

Deep Reinforcement Learning for Dynamic Treatment Regimes on Medical Registry Data [PDF]

arXiv, 2018
This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state spaces than existing reinforcement learning methods to model real-life complexity in heterogeneous disease ...
arxiv  

Mechanics of polymer brush based soft active materials -- theory and experiments [PDF]

, 2018
Brush-like structures emerge from stretching of long polymer chains, densely grafted on to the surface of an impermeable substrate. They arise due to the competition between conformational entropic elasticity of polymer chains and excluded volume interactions from the intra and interchain monomer repulsions.
arxiv   +1 more source

Graft-versus-host disease versus graft-versus-leukemia [PDF]

Hematology, 2015
Abstract Graft-versus-host disease (GVHD) is a significant clinical problem after allogenic hematopoietic cell transplantation (HCT) associated with substantial morbidity and mortality that limits the potential utility of transplantation.
openaire   +3 more sources

Alloreactivity: the Janus-face of hematopoietic stem cell transplantation [PDF]

, 2017
Differences in major and minor histocompatibility antigens between donor and recipient trigger powerful graft-versus-host reactions after allogeneic hematopoietic stem cell transplantation (HSCT).
Apperley, J. (Jane), Brand, R. (René), Cornelissen, J.J. (Jan), Dreger, P. (Peter), Duarte, R.F. (Rafael), Gratwohl, A. (Alois), Greinix, H.T. (H. T.), Kroeger, N. (Nicolaus), Lanza, F. (F.), Mc Grath, E. (E.), Nagler, A. (Arnon), Niederwieser, D. (Dietger), Snowden, J. (John), Sureda, A. (Anna)   +13 more
core   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Sensitivity of changes in chronic graft-versus-host disease activity to changes in patient-reported quality of life: results from the Chronic Graft-versus-Host Disease Consortium

Haematologica, 2011
Background The 2005 National Institute of Health Chronic Graft-versus-Host Disease Consensus Conference recommended collection of patient-reported outcomes in clinical trials on chronic graft-versus-host disease.
Joseph Pidala, Brenda F. Kurland, Xiaoyu Chai, Georgia Vogelsang, Daniel J. Weisdorf, Steven Pavletic, Corey Cutler, Navneet Majhail, Stephanie J. Lee   +8 more
doaj   +1 more source

Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease [PDF]

arXiv, 2016
The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single ...
arxiv