Results 111 to 120 of about 8,034,026 (305)

DETERMINANTS OF PEDIATRIC HAPLOIDENTICAL HEMATOPOIETIC CELL TRANSPLANTATION (HCT) WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE (PT-CY): THE INFLUENCE OF DONOR CHARACTERISTICS

Hematology, Transfusion and Cell Therapy
Introduction: Donor age and relationship has emerged as a key modifiable variable in haploidentical hematopoietic cell transplantation, with younger and sibling donors associated with reduced non-relapse mortality and graft-versus-host disease in adult ...
Luiza Dornelles Penteado PACHECO E SILVA, Ana Carolina Ribeiro CORREA, Aline Ferrari MARTINS, Ana Cláudia Ramos Donatelli BRONZONI, Laís Lima QUINTINO, Maria Gabriela Alves Dias MATOS, Luciana Dos Santos DOMINGUES, Valéria Cortez GINANI, Roseane Vasconcelos GOUVEIA, Raisa Machado AMARAL, Fernanda De Oliveira MOTA, Lahis Cardoso de CASTRO, Maria De Los Angeles Duran SALAS, Lucas Augusto Monetta da SILVA, Beatriz Vale FARKAS, Yohanna Bastani de MATTOS, Mayara Satsuki KUNII, Adriane Da Silva Santos IBANEZ, Cintia Monteiro LUSTOSA, Camilla Margarida Maria Soares de Sousa PARRODE, Vanessa Aparecida do Nascimento VARJAO, Olga Margareth Wanderley de Oliveira FéLIX, Cristiane Menezes Vitoria ALFERI, Adriana SEBER   +23 more
doaj   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Characterization of a subpopulation in neonatal thymus which suppresses the graft-vs.-host reaction

, 1983
Thymus cells from neonatal and infant mice were found to have a high capacity to prevent mortality from acute graft-vs-host disease as compared with spleen cells from stable radiation chimeras.
Knaan Shanzer, S., Bekkum, D.W. van
core  

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Manipulating the Immunologic Characteristics of Both Graft and Host to Improve Transplant Outcome

, 1998
Background Several critical outcomes of allogeneic stem cell transplantation for hematologic malignancies such as engraftment, incidence of graft-vs-host disease (GVHD) and disease-free survival depend on a balance between residual host and infused donor
Stephen J. Noga, Paul V. O'donnell
core   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source

Immunologic tolerance to skin allograft after graft-versus-host disease.

, 2007
We report the observation of a young girl suffering from acute myeloid luekemia who developed chronic graft-versus-host disease with major skin involvement after a bone marrow graft from her histocompatible brother. She developed an immunologic tolerance
VanWijck, Romain R, Weynand, Birgit, Elias, Badwi, Elias, Badwi Georges, Vanwijck, Romain, Meunier, Daniel I, Squifflet, Jean Paul, Meunier, Daniel, Marot, Liliane, Bayet, Bénédicte   +9 more
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Brazilian guideline for oral graft-versus-host disease: Recommendations from the Brazilian Society of Bone Marrow Transplantation

Journal of Bone Marrow Transplantation and Cellular Therapy
Oral chronic graft-versus-host disease (cGVHD) is a frequent and clinically heterogeneous manifestation after allogeneic hematopoietic cell transplantation (HCT).
LEANDRO Dorigan DE MACEDO, Mariana Andrade Costa, Fernanda de Paula Eduardo, Leticia Mello Bezinelli, Paulo Sergio da Silva Santos, Heliton Spíndola Antunes, Maria Elvira Pizzigatti Correa   +6 more
doaj   +1 more source

Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease

, 2019
The immune-mediated tissue destruction of graft-vs-host disease (GvHD) remains a major barrier to greater use of hematopoietic stem cell transplantation (HSCT).
E. Ilker Ozay, Joe A. Torres, Barbara A. Osborne, Heather L. Sherman, Gregory N. Tew, Ross A. Macdonald, Jyothi Vijayaraghavan, Igor I. Slukvin, Lisa M. Minter, Daniel T. Garrigan, Jr., Kilian Kelly, Karthik Chandiran, Sudarvili Shanthalingam, Gabriela Gonzalez-Perez   +13 more
core   +1 more source