Results 211 to 220 of about 160,953 (345)

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Correction to: "Severe Hypertriglyceridemia in a Patient Treated With Sirolimus for Graft-vs-Host Disease Prophylaxis". [PDF]

JCEM Case Rep
europepmc   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source

Immunological Tolerance: One of Biology's Most Intriguing Mysteries [PDF]

, 1999
Bach FH, Barnard CN, Billingham RE, Calne RY, Calne RY, Carrel A, Dausset J, Demirleau, Derom F, Gatti RA, Gibson T, Goodwin WE, Groth CG, Hamburger J, Kuss R, Lillehei RC, Mazariegos GV, Meeker W, Merrill JP, Moore FD, Moore FD, Murray JE, Owen RD, Przepiorka D, Ramos HC, Schwartz R, Schwartz R, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Thomas ED, Wessman M, Zinkernagel RM, Zinkernagel RM, Zukoski CF   +48 more
core   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Histopathologic Grading of Acute Cutaneous Graft-vs-Host Disease and Nonrelapse Mortality.

JAMA Dermatol
Chen J, Raymundo C, Martinez A, Lee SJ, Stevenson PA, Shinohara MM.   +5 more
europepmc   +1 more source

Study protocol: Close Assessment and Testing for Chronic Graft-vs.-Host disease (CATCH). [PDF]

PLoS One
Pidala J, Carpenter PA, Onstad L, Pavletic SZ, Hamilton BK, Chen GL, Farhadfar N, Hall M, Lee SJ.   +8 more
europepmc   +1 more source

Cell migration, chimerism, and graft acceptance: A new view of organ transplantation [PDF]

, 1994
Cillo, U, Demetris, AJ, Murase, N, Ricordi, C, Starzl, TE, Trucco, M   +5 more
core  

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease

Mucosal Immunology, 2016
F. Malard, Béatrice Gaugler, Béatrice Gaugler, B. Lamarthée, B. Lamarthée, M. Mohty, M. Mohty   +6 more
semanticscholar   +1 more source