Results 271 to 280 of about 160,953 (345)

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation. [PDF]

Immunity
Yeh AC, Koyama M, Waltner OG, Minnie SA, Boiko JR, Shabaneh TB, Takahashi S, Zhang P, Ensbey KS, Schmidt CR, Legg SRW, Sekiguchi T, Nelson E, Bhise SS, Stevens AR, Goodpaster T, Chakka S, Furlan SN, Markey KA, Bleakley ME, Elson CO, Bradley PH, Hill GR.   +22 more
europepmc   +1 more source

Radiological Findings Post Autologous Fat Grafting and Breasts Procedures: Avoiding False Positive Results

ANZ Journal of Surgery, EarlyView.
This article highlights the importance of understanding the imaging features and complications of fat necrosis and oil cysts to improve diagnostic accuracy and clinical management. A rational diagnostic sequence—emphasizing comparison with prior imaging, careful evaluation of morphological changes, and judicious use of biopsy—can reduce unnecessary ...
Eduardo de Faria Castro Fleury
wiley   +1 more source

The Impact of Obesity on Durable Left Ventricular Assist Device Implantation: A Systematic Review and Meta‐Analysis

Artificial Organs, EarlyView.
14 100 LVAD patients across 21 studies were analyzed. Findings indicated that obese LVAD recipients had lower short‐term mortality and higher risk of infection, thrombosis and right heart failure. There was no difference in long‐term survival between obese and non‐obese patients.
Hugh Jacobs, Olivia Frost, Arian Arjomandi Rad, Wing Kiu Chou, Sadeq Al‐Saegh, Alina Zubarevich, Alexander Weymann, Arjang Ruhparwar, Lukman Amanov, Peyman Sardari Nia, Antonios Kourliouros, Thanos Athanasiou   +11 more
wiley   +1 more source

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Role of extracorporeal photopheresis in the management of children with graft‐vs‐host disease

Journal of clinical apheresis, 2022
Graft‐vs‐host disease (GVHD) is a frequent cause of morbidity and mortality in allogeneic stem cell transplants. Extracorporeal photopheresis (ECP) is one of the most accepted second‐line treatments, but technical issues of ECP in children might be ...
P. Asensi Cantó, J. Sanz Caballer, C. Fuentes Socorro, P. Solves Alcaina, P. Lloret Madrid, J. Solís Ruíz, Bárbara Torres Guerola, J. de la Rubia Comos, J. Fernández Navarro, I. Gómez-Seguí   +9 more
semanticscholar   +1 more source

Graft-vs.-Host Disease

Critical Reviews in Oral Biology & Medicine, 1997
Bone marrow transplantation (BMT) is the treatment of choice for many leukemias, lymphomas, bone marrow failure syndromes, and immundeficiency disorders, and is the primary and salvage therapy for many solid malignancies. With the establishment of national and international marrow banks, unrelated allogeneic BMT is being performed with increasing ...
S B, Woo, S J, Lee, M M, Schubert
openaire   +2 more sources

Chronic Graft-vs-Host Disease

JAMA, 2003
ALLOGENEIC HEMATOPOIETIC cell transplantation (HCT) is a treatment used increasingly for a variety of malignant and nonmalignant diseases of the bone marrow and immune system. Although the procedure cures many patients with otherwise incurable diseases, it is often associated with serious immunological complications, particularly graft-vs-host disease (
Vikas, Bhushan, Robert H, Collins
openaire   +2 more sources

Post-Transplantation Cyclophosphamide vs Tacrolimus and Methotrexate Graft-versus-Host Disease Prophylaxis For HLA-Matched Donor Transplantation.

Transplantation and Cellular Therapy, 2022
BACKGROUND The use of post-transplantation cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis is increasing in patients undergoing HLA-matched sibling (MSD) or unrelated (MUD) donor hematopoietic cell transplantation (HCT), but data
R. Mehta, R. Saliba, G. Rondon, G. Al-Atrash, Q. Bashir, C. Hosing, P. Kebriaei, I. Khouri, Y. Nieto, B. Oran, U. Popat, M. Qazilbash, J. Ramdial, S. Srour, R. Champlin, K. Rezvani, E. Shpall, A. Alousi   +17 more
semanticscholar   +1 more source

Hepatitic Variant of Graft-vs-Host Disease

American Journal of Clinical Pathology, 2022
Abstract Objectives Graft-vs-host disease (GVHD) of the liver is a complication of allogeneic hematopoietic stem cell transplantation with hepatitic and classic variants. We determined the percentage of hepatitic variant cases, compared clinicopathologic features of the two groups, and assessed ...
Tom Z Liang, Stephen Dong, Mike Fang, Yuna Gong, George Yaghmour, Shefali Chopra   +5 more
openaire   +2 more sources