Results 1 to 10 of about 13,349 (202)

Real-world data and clinical experience from over 100,000 multi-cancer early detection tests [PDF]

Nature Communications
Blood-based multi-cancer early detection (MCED) has the potential to simultaneously screen for multiple deadly cancers with high positive predictive value. To assess real-world performance, we evaluated the Galleri® MCED test (GRAIL, Inc.) across 111,080
Marc Matrana, Vershalee Shukla, Dallas Kingsbury, Martin Poliak, Jordan Lipton, Matthew McMillin, Louis B. Malinow, Oliver Venn, John F. Beausang, Geoff Stanley, Earl Hubbell, Kathryn N. Kurtzman, Jeffrey M. Venstrom, Rita Shaknovich, Candace Westgate   +14 more
doaj   +2 more sources

Comparing Two Equations for Estimation of Kidney Function (Cock-croft-Gault and Glomerular Filtration Rate Assessment in Liver Disease) for Vancomycin Dosing in Adult Liver Transplant Recipients: A Pilot, Randomized Clinical Trial [PDF]

Pharmaceutical Sciences, 2022
Background: In the setting of impaired liver function, estimation of glomerular filtration rate (GFR) using common creatinine-based equations is inaccurate.
Yasaman Saee, Simin Dashti-Khavidaki, Zahra Ahmadinejad, Fereshteh Ghiasvand   +3 more
doaj   +1 more source

Problematyka killer acquisitions w świetle wyroku w sprawie Illumina/Grail przeciwko Komisji Europejskiej [PDF]

internetowy Kwartalnik Antymonopolowy i Regulacyjny, 2022
Artykuł porusza problematykę tzw. zabójczych przejęć w świetle orzeczenia Illumina/Grail v. Komisji. Autorzy artykułu wyjaśniają na czym polegają trudności związane z tzw.
Damian Kopera, Filip Wiliński
doaj   +1 more source

A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection

Nature Communications, 2021
Cell-free RNA (cfRNA) is a promising analyte for cancer diagnosis. Here, the authors determine the baseline cell-free transcriptome in the absence of cancer and identify tissue- and subtype-specific cfRNA biomarkers in breast and lung cancer patients.
Matthew H. Larson, Wenying Pan, Hyunsung John Kim, Ruth E. Mauntz, Sarah M. Stuart, Monica Pimentel, Yiqi Zhou, Per Knudsgaard, Vasiliki Demas, Alexander M. Aravanis, Arash Jamshidi   +10 more
doaj   +1 more source

Patient-reported outcomes associated with cancer screening: a systematic review

BMC Cancer, 2022
Background Multi-cancer early detection tests have been developed to enable earlier detection of multiple cancer types through screening. As reflected by patient-reported outcomes (PROs), the psychosocial impact of cancer screening is not yet clear.
Ashley Kim, Karen C. Chung, Christopher Keir, Donald L. Patrick   +3 more
doaj   +1 more source

The Wagnerian Layer in I. Annensky’s Poetry

Вестник Кемеровского государственного университета, 2022
Passion for R. Wagner’s music and aesthetic ideas was characteristic of the Art Nouveau culture. At the turn of the XIX–XX centuries, it affected the Symbolist theater and shaped the aesthetic and artistic worlds of many Russian authors.
N. V. Nalegach
doaj   +1 more source

Breast, Colorectal, Lung, Prostate, and Cervical Cancer Screening Prevalence in a Large Commercial and Medicare Advantage Plan, 2008–2020

Preventive Medicine Reports, 2022
This study aimed to comprehensively assess breast, colorectal, cervical, lung, and prostate cancer screening rates and trends in the United States over time among individuals for whom screening is recommended by the United States Preventive Services Task
Ashley Kim, Matthew Gitlin, Ela Fadli, November McGarvey, Ze Cong, Karen C. Chung   +5 more
doaj   +1 more source

Reproducibility and Validity of the 6-Minute Walk Test Using the Gait Real-Time Analysis Interactive Lab in Patients with COPD and Healthy Elderly. [PDF]

PLoS ONE, 2016
The 6-minute walk test (6MWT) in a regular hallway is commonly used to assess functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD).
Wai-Yan Liu, Kenneth Meijer, Jeannet M Delbressine, Paul J Willems, Frits M E Franssen, Emiel F M Wouters, Martijn A Spruit   +6 more
doaj   +1 more source

MELD-GRAIL and MELD-GRAIL-Na Are Not Superior to MELD or MELD-Na in Predicting Liver Transplant Waiting List Mortality at a Single-center Level

Transplantation Direct, 2022
Background. Controversy exists regarding the best predictive model of liver transplant waiting list (WL) mortality. Models for end-stage liver disease–glomerular filtration rate assessment in liver disease (MELD-GRAIL) and MELD-GRAIL-Na were recently ...
John D. Chetwood, MBBS(Dist), DTM&H, Mark V. Wells, BSc, Tatiana Tsoutsman, PhD, Carlo Pulitano, MD, PhD, FRACS, Michael D. Crawford, MBBS, FRACS, M.Med, Ken Liu, BSc(Med), FRACP, Simone I. Strasser, MBBS, MD, FRACP, FAASLD, Geoffrey W. McCaughan, MBBS, PhD, FRACP, FAHMS, Avik Majumdar, MPHTM, PhD, FRACP   +8 more
doaj   +1 more source

GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection. [PDF]

PLoS Neglected Tropical Diseases, 2017
BACKGROUND:Trypanosoma cruzi infection is associated with severe T cell unresponsiveness to antigens and mitogens and is characterized by decreased IL-2 synthesis.
Cinthia C Stempin, Jorge D Rojas Marquez, Yamile Ana, Fabio M Cerban   +3 more
doaj   +1 more source