Results 41 to 50 of about 44,937 (300)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Influence of the Combine Harvester Parameter Settings on Harvest Losses

Acta Technologica Agriculturae, 2018
This paper deals with the relationship between grain yield and grain losses during harvest. Measurements were carried out on a combine harvester with axial harvesting device allowing various adjustments to combine harvester parameter settings, such as ...
Šotnar Martin, Pospíšil Jiří, Mareček Jan, Dokukilová Tereza, Novotný Vojtěch   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Importance of low-angle grain boundaries in YBa2Cu3O7-delta coated conductors

, 2008
Over the past ten years the perception of grain boundaries in YBa2Cu3O7−δ conductors has changed greatly. They are now not a problem to be eliminated, but an inevitable and potentially favourable part of the material.

core   +1 more source

Specific manifestation of enzymomycotic depletion of grain on crop losses

Біологічні студії, 2023
Background. Enzymomycotic depletion of grain leads to a significant decrease in the dry matter mass of the grain, as the intensity of respiration increases, protein substances break down, enzymes (in particular, α-amylase) pass from the adsorbed form to ...
Ihor Voloshchuk, Oleksandra Voloshchuk, Oleh Stasiv, Halyna Panakhyd, Valentyna Hlyva, Halyna Bilovus, Ulyana Ilchyniak, Oksana Mamchur, Oksana Kovalchuk   +8 more
doaj   +1 more source

PRODUCTION AND RECOIL LOSS OF COSMOGENIC NUCLIDES IN PRESOLAR GRAINS [PDF]

The Astrophysical Journal, 2016
ABSTRACT Presolar grains are small particles that condensed in the vicinity of dying stars. Some of these grains survived the voyage through the interstellar medium (ISM) and were incorporated into meteorite parent bodies at the formation of the Solar System.
Reto Trappitsch, Ingo Leya
openaire   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Storing soybeans (Glycine max) in silo bags: economic outcomes and grain loss risk

Revista de la Facultad de Ciencias Agrarias, 2020
Silo bags have the potential to increase grain marketing efficiency and to give farmers additional bargaining power. However, silo bags are prone to tearing that can cause grain losses. This article assesses the economic outcomes of storing soybeans
Hernán A. Urcola, Ricardo E. Bartosik
doaj