Results 51 to 60 of about 134,253 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Characterization of grain nutritional quality in wheat [PDF]

Indian Journal of Plant Physiology, 2013
Ten Indian wheat varieties viz. RSP-566, RSP-561, PBW-396, HD-2687, C-306, PBW-175, RSP-81, PBW-550, DBW-17 and WH-542 were characterized for grain nutritional quality parameters viz., macronutrients (viz. starch, protein, protein fractions, sugars, fat), essential elements (calcium, phosphorus, iron and zinc), carotenoids, antioxidant and ...
Mallick, S. A., Azaz, Kousar, Gupta, Moni, Sharma, Vikas, Sinha, B. K.   +4 more
openaire   +2 more sources

Molecular Research for Cereal Grain Quality

International Journal of Molecular Sciences, 2023
Cereals such as wheat (Triticum aestivum L [...]
Jinsong Bao, Jian-Hong Xu
openaire   +2 more sources

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Effect of Grinded Particle Size on the Determination of Aflatoxin B1 in Maize Evaluated by Fractional Preparation Method

Liang you shipin ke-ji, 2023
To evaluate the influence of grinded particle size on the determination of aflatoxin B1(AFB1), improve the sample preparation method and the repeatability of the current national standard detection method for the determination of AFB1 of corn raw grain ...
ZHANG Yan, WU Qian-kun, HAN Yi-tao, JIANG Yan, XIE Gang   +4 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Metabolomic analysis of rice cultivars from diverse production areas [PDF]

PeerJ
Rice grown in Yunnan Province is known for its excellent taste and consumer preference. However, the metabolite composition of this unique rice remains unclear.
Xuheng Nie, Shuiyan Yang, Ying Guo, Xin Wang, Yunman Wen, Chao Liu, Fuying Liu   +6 more
doaj   +2 more sources

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Comparison of the Nutritional Values of Quinoa in Four Different Colors

Liang you shipin ke-ji
To compare the nutritional values of different colored quinoa, four main varieties of white, black, red, and gray quinoa from China's major quinoa-producing provinces were selected.
LIU Jian-lei, ZHANG Dong, WANG Wen-juan, YANG Wei-qiao, SUN Hui, DUAN Xiao-liang   +5 more
doaj   +1 more source