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Antibiotic uptake into gram-negative bacteria
European Journal of Clinical Microbiology & Infectious Diseases, 1988Antibiotics taken up into gram-negative bacteria face two major diffusion barriers, the outer and cytoplasmic membranes. Of these, the former has been most studied and is discussed in detail here. Evidence from antibiotic MIC studies on porin-deficient mutants compared with their porin-sufficient parent strains has provided strong support for the ...
Angus Bell, Robert E. W. Hancock
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Detecting Gram-negative bacteria [PDF]
Science Signaling, 2015 Eukaryotic cells use the host protein TIFA to sense the monosaccharide HBP, derived from Gram-negative bacteria.
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2001
The cell wall of Gram-negative bacteria has a very distinctive layered look under the electron microscope and is dramatically different from the Gram-positive cell wall. The inner layer consists of a thin peptidoglycan layer; the outer layer or outer membrane is a protein containing bilayer.
Robert P. Rapp, Kenneth E. Record
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The cell wall of Gram-negative bacteria has a very distinctive layered look under the electron microscope and is dramatically different from the Gram-positive cell wall. The inner layer consists of a thin peptidoglycan layer; the outer layer or outer membrane is a protein containing bilayer.
Robert P. Rapp, Kenneth E. Record
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Resistance in gram-negative bacteria: Enterobacteriaceae
American Journal of Infection Control, 2006The emergence and spread of resistance in Enterobacteriaceae are complicating the treatment of serious nosocomial infections and threatening to create species resistant to all currently available agents. Approximately 20% of Klebsiella pneumoniae infections and 31% of Enterobacter spp infections in intensive care units in the United States now involve ...
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Fever and the control of gram-negative bacteria
Research in Microbiology, 1994Although it seems obvious that fever has some important general adaptive value, it is still not clear by what means this function is manifested. One postulate is that febrile conditions result in the sequestration of soluble iron, effectively starving some pathogens of that essential nutrient.
M.H. Green +2 more
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Resistance mechanisms in Gram-negative bacteria
Medicina Intensiva (English Edition), 2022Enterobacterales resistant to carbapenems or producing extended-spectrum β-lactamases (ESBL) and non-fermenters resistant to carbapenems present resistance to many of the antimicrobials commonly used in clinical practice, and have been recognized by the World Health Organization as a critical priority for the development of new antimicrobials.
Lepe, José A. +1 more
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The Envelope of Gram-Negative Bacteria
1984Examination of high-resolution electron micrographs of sections through Gram-negative and Gram-positive bacteria reveals gross morphological differences. The cytoplasmic membrane of Gram-positive bacteria is encased with a thick peptidoglycan layer and in some species an extracellular capsule (Figure 3.1). The envelope of Gram-negative bacteria is more
Stephen M. Hammond +2 more
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Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria [PDF]
, 2010 Endotoxin refers lipopolysaccharide that constitutes the outer leaflet of the outer membrane of most Gram-negative bacteria. Lipopolysaccharide is comprised of a hydrophilic polysaccharide and a hydrophobic component known as lipid A which is responsible for the major bioactivity of endotoxin.
Peter J. Quinn, Xiaoyuan Wang
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Corneal Rings With Gram-Negative Bacteria
Archives of Ophthalmology, 1977Corneal rings have been described with corneal ulcerations caused by Gram-negative bacteria. Corneal rings were produced by intracorneal injections of viable Pseudomonas aeruginosa as well as heat-inactivated suspensions of Gram-negative bacteria (P aeruginosa and Escherichia coli) but not Gram-positive bacteria (Staphylococcus aureus) or Freund's ...
James Gallo +4 more
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2009
Gram-negative bacteria are responsible for a broad array of infections in both the ambulatory and hospital settings. Urinary tract infections, otitis media, pneumonia, abdominal infections, and meningitis are among the common and serious diseases caused by these pathogens. Beta-lactams including penicillins, cephalosporins, monobactams, and carbapenems,
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Gram-negative bacteria are responsible for a broad array of infections in both the ambulatory and hospital settings. Urinary tract infections, otitis media, pneumonia, abdominal infections, and meningitis are among the common and serious diseases caused by these pathogens. Beta-lactams including penicillins, cephalosporins, monobactams, and carbapenems,
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