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Background Pseudomonas aeruginosa is a common pathogen causing hospital-acquired infections. Carbapenem resistance in P. aeruginosa is either mediated via a combination of efflux pumps, AmpC overexpression, and porin loss, or through an acquired ...
Elena Schäfer+7 more
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Drug-resistant Acinetobacter baumannii (A. baumannii) infections are a critical global problem, with limited treatment choices. This study aims to determine the in vitro activities of colistin–sitafloxacin combinations against multidrug-, carbapenem- and
Vipavee Rodjun+6 more
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Solvent tolerance in Gram-negative bacteria
Bacteria have been found in all niches explored on Earth, their ubiquity derives from their enormous metabolic diversity and their capacity to adapt to changes in the environment. Some bacterial strains are able to thrive in the presence of high concentrations of toxic organic chemicals, such as aromatic compounds, aliphatic alcohols and solvents.
Segura, Ana+6 more
openaire +5 more sources
Role of the cell-wall structure in the retention of bacteria by microfiltration membranes [PDF]
This experimental study investigates the retention of bacteria by porous membranes. The transfer of bacteria larger than the nominal pore size of microfiltration track-etched membranes has been studied for several kinds of bacterial strains.
Aimar, Pierre+3 more
core +1 more source
Extended-spectrum ß-lactamases in gram negative bacteria
Extended-spectrum ß-lactamases (ESBLs) are a group of plasmid-mediated, diverse, complex and rapidly evolving enzymes that are posing a major therapeutic challenge today in the treatment of hospitalized and community-based patients.
Deepti Rawat, Deepthi Nair
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On the essentiality of lipopolysaccharide to Gram-negative bacteria [PDF]
Lipopolysaccharide is a highly acylated saccharolipid located on the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is critical to maintaining the barrier function preventing the passive diffusion of hydrophobic solutes such as antibiotics and detergents into the cell.
Ge Zhang+2 more
openaire +3 more sources
Acquisition of siderophores in Gram-negative bacteria
The outer membrane of Gram-negative bacteria constitutes a permeability barrier that protects the cell from exterior hazards, but also complicates the uptake of nutrients. In the case of iron, the challenge is even greater, because of the scarcity of this indispensable element in the cell's surroundings.
Faraldo-Gómez, J, Sansom, M
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Destabilization of α-helical structure in solution improves bactericidal activity of antimicrobial peptides: Opposing effects on bacterial and viral targets [PDF]
We have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. Here we show that the formulation of peptides LL37 and magainin-2B amide in polysorbate 20 (Tween-20™) results in greater reductions in virus ...
Beck, Konrad+4 more
core +2 more sources
The oxidation of methanol in gram-negative bacteria [PDF]
This is a brief review of the structure and interaction of methanol dehydrogenase and its electron acceptor cytochrome cL, their regulation by modifier protein, and the synthesis and assembly of the ‘methanol oxidase’ system.
openaire +3 more sources
Microbial community dynamics during composting of sewage sludge and straw studied through phospholipid and neutral lipid analysis [PDF]
The composting process involves a succession of different communities of microorganisms that decompose the initial material, transforming it into a stable final product. In thiswork, the levels of phospholipid fatty acid (PLFA), neutral lipid fatty acid (
Amir, Soumia+5 more
core +2 more sources