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BACTERIAL OUTER MEMBRANE VESICLES AND VACCINE APPLICATIONS [PDF]

Frontiers in Immunology, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of self ...
Reinaldo eAcevedo, Sonsire eFernandez, Caridad eZayas, Armando eAcosta, Maria Elena Sarmiento, Valerie A Ferro, Einar eRosenqvist, Concepcion eCampa, Daniel eCardoso, Luis eGarcia, Jose Luis Perez   +10 more
doaj   +8 more sources

Antibiotics and hexagonal order in the bacterial outer membrane [PDF]

Nature Communications, 2023
Georgina Benn, Thomas J. Silhavy, Colin Kleanthous, Bart W. Hoogenboom   +3 more
doaj   +5 more sources

Biomimetic Lipopolysaccharide‐Free Bacterial Outer Membrane‐Functionalized Nanoparticles for Brain‐Targeted Drug Delivery

Advanced Science, 2022
The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia coli K1 (EC‐K1) binding to and invasion of BBB endothelial cells in bacterial ...
Haiyan Chen, Mengyuan Zhou, Yuteng Zeng, Tongtong Miao, Haoyuan Luo, Yang Tong, Mei Zhao, Rui Mu, Jiang Gu, Shudi Yang, Liang Han   +10 more
doaj   +2 more sources

Contribution of bacterial outer membrane vesicles to innate bacterial defense [PDF]

BMC Microbiology, 2011
Background Outer membrane vesicles (OMVs) are constitutively produced by Gram-negative bacteria throughout growth and have proposed roles in virulence, inflammation, and the response to envelope stress.
Manning Andrew J, Kuehn Meta J
doaj   +3 more sources

Bacterial outer membrane vesicles in the fight against cancer [PDF]

Chinese Medical Journal
. Bacterial outer membrane vesicles (OMVs) are diminutive vesicles naturally released by Gram-negative bacteria. These vesicles possess distinctive characteristics that attract attention for their potential use in drug administration and immunotherapy in
Yiming Meng, Cuicui Kong, Yushu Ma, Jing Sun, Guirong Zhang, Xiangxiang Pan   +5 more
doaj   +2 more sources

Commensal bacterial outer membrane protein A induces interleukin-22 production [PDF]

Cell Reports
Summary: Interleukin (IL)-22 promotes host-microbiota homeostasis. We sought to identify microbiota metabolite(s) that drive intestinal IL-22 production.
Yanling Wang, Vu L. Ngo, Jun Zou, Andrew T. Gewirtz   +3 more
doaj   +2 more sources

Do Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease? [PDF]

Journal of Parkinson’s Disease
Parkinson’s disease (PD) is an increasingly common neurodegenerative disease. It has been suggested that the etiology of idiopathic PD is complex and multifactorial involving environmental contributions, such as viral or bacterial infections and ...
Tiana F. Koukoulis, Leah C. Beauchamp, Maria Kaparakis-Liaskos, Rachel M. McQuade, Adityas Purnianto, David I. Finkelstein, Kevin J. Barnham, Laura J. Vella   +7 more
doaj   +2 more sources

Bacterial outer membrane vesicle-based cancer nanovaccines

Cancer Biology & Medicine, 2022
Tumor vaccines, a type of personalized tumor immunotherapy, have developed rapidly in recent decades. These vaccines evoke tumor antigen-specific T cells to achieve immune recognition and killing of tumor cells.
Xiaoyu Gao, Qingqing Feng, Jing Wang, Xiao Zhao   +3 more
doaj   +1 more source

A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance

Applied Sciences, 2023
Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment.
Ishan Ghai
doaj   +1 more source

A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice.

PLoS Pathogens, 2022
As pathogenic bacteria become increasingly resistant to antibiotics, antimicrobials with mechanisms of action distinct from current clinical antibiotics are needed.
Jamie L Dombach, Joaquin Lj Quintana, Samual C Allgood, Toni A Nagy, Daniel L Gustafson, Corrella S Detweiler   +5 more
doaj   +1 more source