Results 1 to 10 of about 1,694,595 (291)

Outer Membrane Vesicles: An Emerging Vaccine Platform

Vaccines, 2022
Vaccine adjuvants are substances that improve the immune capacity of a recombinant vaccine to a great extent and have been in use since the early 1900s; they are primarily short-lived and initiate antigen activity, mainly an inflammatory response.
Dharmendra Kashyap, Mrutyunjaya Panda, Budhadev Baral, Nidhi Varshney, Sajitha R, Vasundhra Bhandari, Hamendra Singh Parmar, Amit Prasad, Hem Chandra Jha   +8 more
doaj   +4 more sources

Quantifying outer membrane permeability to β-lactam antibiotics using outer membrane vesicles that protect antibiotic-susceptible bacteria [PDF]

Nature Communications
The development of innovative methods for quantitatively assessing drug efficacy is essential for advancing effective treatments against antibiotic-resistant bacteria.
Alicja Razew, Quentin Herail, Isabel Ayala, Myriam Guissouma, Michel Arthur, Jean-Pierre Simorre   +5 more
doaj   +2 more sources

Membrane Vesicles as Drug Delivery Systems: Source, Preparation, Modification, Drug Loading, In Vivo Administration and Biodistribution, and Application in Various Diseases

Pharmaceutics, 2023
Bioinspired (or biologically inspired) drug delivery systems (DDSs) have been intensively studied in the last decades. As bioinspired DDSs, membrane vesicles, including extracellular vesicles (EVs) released from eukaryotic cells, outer membrane vesicles (
Chenhan Sun, Ying Qin, Hongda Zhuang, Yuan Zhang, Zhiwen Wu, Yong Chen   +5 more
doaj   +1 more source

The Role of Vesicles in Transporting of Cholera Toxin

Проблемы особо опасных инфекций, 2023
The review reports on the secretion pathways of the main virulence factor of Vibrio cholerae, cholera toxin, both through the two-stage Sec-dependent type 2 secretion system and with the help of vesicles of the outer membrane of V. cholerae.
V. P. Zyuzina, O. A. Yakusheva, L. P. Alekseeva, V. V. Evdokimova, D. I. Simakova   +4 more
doaj   +1 more source

Aberrant Membrane Structures in Hypervesiculating Escherichia coli Strain ΔmlaEΔnlpI Visualized by Electron Microscopy

Frontiers in Microbiology, 2021
Escherichia coli produces extracellular vesicles called outer membrane vesicles (OMVs) by releasing a part of its outer membrane. We previously reported that the combined deletion of nlpI and mlaE, related to envelope structure and phospholipid ...
Yoshihiro Ojima, Tomomi Sawabe, Mao Nakagawa, Yuhei O. Tahara, Yuhei O. Tahara, Makoto Miyata, Makoto Miyata, Masayuki Azuma   +7 more
doaj   +1 more source

The Role of Outer Membrane Vesicles of Agents of Particularly Dangerous Infections in the Pathogenesis and Immunogenesis of Infectious Process

Проблемы особо опасных инфекций, 2022
The literature review is devoted to the modern concepts of the vesiculation phenomenon and its biological role in pathogenic bacteria – causative agents of particularly dangerous human infections.
N. V. Aronova, N. V. Pavlovich, M. V. Tsimbalistova, S. N. Golovin, A. S. Anisimova   +4 more
doaj   +1 more source

Solution nuclear magnetic resonance spectroscopy of bacterial outer membrane proteins in natively excreted vesicles using engineered Escherichia coli

MicrobiologyOpen, 2022
Gaining structural information on membrane proteins in their native lipid environment is a long‐standing challenge in molecular biology. Instead, it is common to employ membrane mimetics, which has been shown to affect protein structure, dynamics, and ...
Mohammed Mouhib, Celestine N. Chi
doaj   +1 more source

Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles. [PDF]

PLoS ONE, 2011
Acinetobacter baumannii is an important nosocomial pathogen that causes a high morbidity and mortality rate in infected patients, but pathogenic mechanisms of this microorganism regarding the secretion and delivery of virulence factors to host cells have
Jong Sook Jin, Sang-Oh Kwon, Dong Chan Moon, Mamata Gurung, Jung Hwa Lee, Seung Il Kim, Je Chul Lee   +6 more
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The Contribution of Membrane Vesicles to Bacterial Pathogenicity in Cystic Fibrosis Infections and Healthcare Associated Pneumonia

Frontiers in Microbiology, 2020
Almost all bacteria secrete spherical membranous nanoparticles, also referred to as membrane vesicles (MVs). A variety of MV types exist, ranging from 20 to 400 nm in diameter, each with their own formation routes.
Jolien Vitse, Bart Devreese
doaj   +1 more source

Outer membrane vesicles: A bacterial-derived vaccination system

Frontiers in Microbiology, 2022
Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and ...
Linda A. Lieberman
doaj   +1 more source