Results 201 to 210 of about 627,357 (262)

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

<i>In vitro</i> activity of ceftaroline against clinical isolates of Gram-positive bacteria in paediatric patients: ATLAS programme 2018-2023. [PDF]

JAC Antimicrob Resist
Kiratisin P, Kuraieva A, Utt E, Esposito S.   +3 more
europepmc   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Statin-induced lipid carrier stress reveals a conserved vulnerability in β-lactam-resistant Gram-positive bacteria. [PDF]

Nat Commun
Torrens G, Bisset SW, López-Bravo M, Johansson AF, Lopez D, Cava F.   +5 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Case Series: Use of Dalbavancin for Invasive Gram-Positive Infection in Children. [PDF]

J Pediatr Pharmacol Ther
Chang AJ, Mannix MK, Kenney PO, Vermilye KN, Rebello GLA, Zwiener J, Hines AG, Sato A, Islam SM, Gómez-Duarte OG, Yu KOA.   +10 more
europepmc   +1 more source

Phenotypic and genotypic antimicrobial resistance profiles of gram-positive cocci and non-fermenting gram-negative rods. [PDF]

Sci Rep
Silva CP, Silva CL, Haq IU, Magalhães PP, de Macêdo Farias L, Dos Santos VL.   +5 more
europepmc   +1 more source

Evaluation of serine protein kinase HPrK as an antibacterial target in gram-positive bacteria and mycoplasmas. [PDF]

Microbiol Spectr
Yan H, Xu J, Jiang T, Lu S, Liu Y, Sun Y, Wu H, Hu Q, Li L, Huang Q, Zhang T, Zhou R.   +11 more
europepmc   +1 more source

Clinical Characteristics, Empirical Antibiotic Appropriateness, and Outcomes of Gram-Positive Versus Gram-Negative Bacteremia in Emergency Department Patients with Sepsis. [PDF]

Medicina (Kaunas)
Kim T, Yoo J, Lee SH, Jung W.
europepmc   +1 more source

Limited association between serum vancomycin pharmacokinetic/ pharmacodynamic indices and clinical outcomes in gram-positive complicated urinary tract infections. [PDF]

Front Pharmacol
Fan Y, Zhao J, Chen Y, Xi L, Wu H, Guo B, Li N, Yang P, Bian Q, Wu J, Zhang J.   +10 more
europepmc   +1 more source