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Repurposing Birabresib to target Gram‑positive bacteria [PDF]

npj Antimicrobials and Resistance
The threat of antibiotic-resistant bacteria is rapidly escalating, creating an urgent need for new types of antimicrobials. Although most antibiotics act by disrupting essential cellular processes, such as cell division, replication, transcription, and ...
Hazera Khatun Koly, Roha Razzaq, Tahmina Hossain, Nicholas C. Butzin   +3 more
doaj   +2 more sources

Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci

Marine Drugs, 2021
New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising.
Janira Prichula, Muriel Primon-Barros, Romeu C. Z. Luz, Ícaro M. S. Castro, Thiago G. S. Paim, Maurício Tavares, Rodrigo Ligabue-Braun, Pedro A. d’Azevedo, Jeverson Frazzon, Ana P. G. Frazzon, Adriana Seixas, Michael S. Gilmore   +11 more
doaj   +1 more source

Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms

Nature Communications, 2022
SCCmec is a large mobile genetic element that confers resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus. Here, the authors show that biofilm growth conditions enhance the efficiency of natural transformation in S.
Mais Maree, Le Thuy Thi Nguyen, Ryosuke L. Ohniwa, Masato Higashide, Tarek Msadek, Kazuya Morikawa   +5 more
doaj   +1 more source

Antibacterial effect of Asphodelus fistulosus aqueous and ethanolic crude extracts on gram positive and gram negative bacteria

Brazilian Journal of Biology, 2022
Asphodelus fistulosus (A. fistulosus) is a wild plant grows in Jordan. Traditionally, it is used to treat different medical conditions and diseases such as respiratory ailments, against burns and dermatomucosal infections.This study aims to find out the ...
M. M. A. Al-Qudah
doaj   +1 more source

Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer

Scientific Reports, 2023
In this work, we investigated the oncogenic role of Streptococcus gallolyticus subsp. gallolyticus (SGG), a gut bacterium associated with colorectal cancer (CRC).
Ewa Pasquereau-Kotula, Giulia Nigro, Florent Dingli, Damarys Loew, Patrick Poullet, Yi Xu, Scott Kopetz, Jennifer Davis, Lucie Peduto, Catherine Robbe-Masselot, Philippe Sansonetti, Patrick Trieu-Cuot, Shaynoor Dramsi   +12 more
doaj   +1 more source

β-Glucan-Producing Pediococcus parvulus 2.6: Test of Probiotic and Immunomodulatory Properties in Zebrafish Models

Frontiers in Microbiology, 2018
Lactic acid bacteria synthesize exopolysaccharides (EPS), which could benefit the host’s health as immunomodulators. Furthermore, EPS could protect bacteria against gastrointestinal stress, favoring gut colonization, thus protecting the host against ...
Adrián Pérez-Ramos, Maria L. Mohedano, Miguel Á. Pardo, Paloma López   +3 more
doaj   +1 more source

Extracellular vesicle production in Gram‐positive bacteria

Microbial Biotechnology, 2022
Summary This is a highlight on the article ‘Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage‐encoded holin‐lysin system’ by Yue Liu, Eddy Smid and Tjakko Abee.
Scott N. Dean, Meghna Thakur, Joseph R. Spangler   +2 more
doaj   +1 more source

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence

mBio, 2018
Staphylococcus aureus causes various diseases ranging from skin and soft tissue infections to life-threatening infections. Adaptation to the different host niches is controlled by a complex network of transcriptional regulators.
Anna Nagel, Stephan Michalik, Michel Debarbouille, Tobias Hertlein, Manuela Gesell Salazar, Hermann Rath, Tarek Msadek, Knut Ohlsen, Jan Maarten van Dijl, Uwe Völker, Ulrike Mäder   +10 more
doaj   +1 more source

Post-neurosurgical meningitis; gram negative bacilli vs. gram positive cocci

Caspian Journal of Internal Medicine, 2022
Background: Post-neurosurgical meningitis is a significant cause of mortality and morbidity. In this study we aimed to compare the differences of clinical, laboratory features and outcomes between the post-neurosurgical meningitis caused by gram-negative
Mehdi Zeinalizadeh, Roya Yazdani, Mohammad Mehdi Feizabadi, Maryam Shadkam, Arash Seifi, Seyed Ali Dehghan Manshadi, Alireza Abdollahi, Mohammadreza Salehi   +7 more
doaj  

Characterization of the Plasmid Encoded Virulence Region pat-1 of Phytopathogenic Clavibacter michiganensis subsp. michiganensis

Molecular Plant-Microbe Interactions, 1997
The tomato pathogen Clavibacter michiganensis subsp. michiganensis NCPPB382, causing bacterial wilt and canker, harbors two plasmids, pCM1 (27.5 kb) and pCM2 (72 kb), carrying genes involved in virulence.
Jens Dreier, Dietmar Meletzus, Rudolf Eichenlaub   +2 more
doaj   +1 more source