Results 31 to 40 of about 627,357 (262)

Antimicrobial and anti-biofilm activity of Hypericum brasiliense extract and its fractions on Staphylococcus of canine origin

Scientific Reports
The growing resistance to antimicrobials, partly due to the ability to form biofilms, poses a challenge for developing new antimicrobial agents. This study assessed the antimicrobial and antibiofilm activity of Hypericum brasiliense extract, Japonicin ...
Yasmim de M. Assumpção, Lialyz S. P. Andre, Izabel M. Teixeira, Carolina O. da Fonseca, Francisco P. Machado, Tainara A. N. Ribeiro, Renata F. A. Pereira, Daniela Sachs, Leandro M. Rocha, Bruno Penna   +9 more
doaj   +1 more source

Induction of intercrypt goblet cells upon bacterial infection: a promising therapeutic target to restore the mucosal barrier

Gut Microbes
Intestinal mucins play a crucial role in the mucosal barrier, serving as the body’s initial defense against microorganisms. However, how the host regulates the secretion and glycosylation of these mucins in response to bacterial invasion remains unclear.
Renaud Léonard, Ewa Pasquereau-Kotula, Edwige Madec, Benjamin Marsac, Adriana Mihalache, Laurence du Merle, Jordan Denis, Corentin Spriet, Philippe Sansonetti, Shaynoor Dramsi, Catherine Robbe Masselot   +10 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Antimicrobial Resistance Profiles in Enterococcus spp. Isolates From Fecal Samples of Wild and Captive Black Capuchin Monkeys (Sapajus nigritus) in South Brazil

Frontiers in Microbiology, 2018
The environment, human, and animals play an important role in the spread of antibiotic-resistant bacteria. Enterococci are members of the gastrointestinal tracts of humans and animals and represent important reservoirs of antibiotic resistance genes ...
Tiela Trapp Grassotti, Dejoara de Angelis Zvoboda, Letícia da Fontoura Xavier Costa, Alberto Jorge Gomes de Araújo, Rebeca Inhoque Pereira, Renata Oliveira Soares, Paulo Guilherme Carniel Wagner, Jeverson Frazzon, Ana Paula Guedes Frazzon   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The SaeRS two-component system regulates virulence gene expression in group B Streptococcus during invasive infection

mBio
Group B Streptococcus (GBS) is a pathobiont responsible for invasive infections in neonates and the elderly. The transition from a commensal to an invasive pathogen relies on the timely regulation of virulence factors. In this study, we characterized the
Francesco Coppolino, Giuseppe Valerio De Gaetano, Cosme Claverie, Odile Sismeiro, Hugo Varet, Rachel Legendre, Angelica Pellegrini, Alessia Berbiglia, Luca Tavella, Germana Lentini, Agata Famà, Giulia Barbieri, Giampiero Pietrocola, Giuseppe Teti, Arnaud Firon, Concetta Beninati   +15 more
doaj   +1 more source

ANTIBACTERIAL ASSAY OF 2’-HYDROXY-4’,6’,4-TRIMETHOXYCHALCONE AND 4-METHOXYCHALCONE AGAINST GRAM POSITIVE AND GRAM NEGATIVE BACTERIA

Jurnal Riset Kesehatan, 2019
Blood transfusion is currently one of the most important health care treatments. Unfortunately, the prevalence of transfusion reactions caused by the use of blood products is still quite high although blood products have been tested in terms of ...
Wiwit Sepvianti, Serafica Btari Christiyani Kusumaningrum   +1 more
doaj   +1 more source

SYNTHESIS, CHARACTERIZATION AND STUDY THE EFFECT OF (3,5-DIMETHYL-1H-PYRAZOL-4- YL) MERCURY (II) CHLORIDE ON GROWTH INHIBITION OF SOME BACTERIA ,YEAST AND SOME FUNGI (IN VITRO). [PDF]

Basrah Journal of Veterinary Research, 2008
The reaction of 3,5-dimethyl-1H-pyrazole with mercury (II)acetate in absolute methanol gave (3,5-dimethyl-1H-pyrazol-4-yl) mercury(II) chloride (DMPMC), which characterized by microanalysis, 1H, and 13C-NMR and IR.
Eman.T.Ali
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source