Results 251 to 260 of about 568,884 (306)

Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria. [PDF]

Future Med Chem
Pei L, Yu X, Shan X, Li G.
europepmc   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

From Antiretroviral to Antibacterial: Deep-Learning-Accelerated Repurposing and In Vitro Validation of Efavirenz Against Gram-Positive Bacteria. [PDF]

Molecules
Saleh E, Soliman OA, Attia N, Rafaat N, Baecker D, Teleb M, Ghazal A, Amer AN.   +7 more
europepmc   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Atomic structures of a bacteriocin targeting Gram-positive bacteria. [PDF]

Nat Commun
Cai X, He Y, Yu I, Imani A, Scholl D, Miller JF, Zhou ZH.   +6 more
europepmc   +1 more source

Unraveling Mechanisms and Engineering Strategies for Superior Photocarrier Dynamics Toward Efficient Photocatalysis

EcoEnergy, EarlyView.
Despite its potential, photocatalysis is limited by inefficient charge carrier separation and transport. This article reviews the mechanisms, characterization methods, and strategies for improvement, concluding with future challenges in the field. ABSTRACT Photocatalysis offers a promising solution to environmental and renewable energy issues. However,
Leqi Cheng, Xin Wang, Yishen Zhang, Xinrong Zhang, Jung‐Ho Yun, Songcan Wang   +5 more
wiley   +1 more source

Global distribution of α/β hydrolase family macrolide esterases in Gram-positive bacteria. [PDF]

ISME J
Zhou Y, Yang Y, Mao Y, Hou Z, Xu Y, Zhao K, Chu Y, Wang X, Wang C, Li S, Xu F, Hao L, Xie B, Lin J, Song T.   +14 more
europepmc   +1 more source

Burden of gram-positive bacteria from urinary tract infection: A four-year retrospective study in a tertiary health setting in southern Saudi Arabia. [PDF]

PLoS One
Alkahtani AM, Alqahtani AJ, Alamri A, Assiry MM, Elfaki M, Shabi YM, Hamid ME.   +6 more
europepmc   +1 more source

Increased Antibiotic Susceptibility of Gram-Positive Bacteria in Cerebrospinal Fluid Compared to Broth. [PDF]

Antibiotics (Basel)
Wirth JS, Djukic M, Biesner K, Reichard U, Nau R, Seele J.   +5 more
europepmc   +1 more source