Results 71 to 80 of about 9,958 (247)

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Chinese Grammatical Error Correction: A Survey

CoRR
Chinese Grammatical Error Correction (CGEC) is a critical task in Natural Language Processing, addressing the growing demand for automated writing assistance in both second-language (L2) and native (L1) Chinese writing. While L2 learners struggle with mastering complex grammatical structures, L1 users also benefit from CGEC in academic, professional ...
Mengyang Qiu, Qingyu Gao, Linxuan Yang, Yang Gu 0004, Tran Minh Nguyen, Zihao Huang, Jungyeul Park   +6 more
openaire   +2 more sources

Large Language Model‐Based Chatbots in Higher Education

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of large language models (LLMs) in higher education can facilitate personalized learning experiences, advance asynchronized learning, and support instructors, students, and researchers across diverse fields. The development of regulations and guidelines that address ethical and legal issues is essential to ensure safe and responsible adaptation
Defne Yigci, Merve Eryilmaz, Ail K. Yetisen, Savas Tasoglu, Aydogan Ozcan   +4 more
wiley   +1 more source

Retinal Vessel Segmentation: A Comprehensive Review From Classical Methods to Deep Learning Advances (1982–2025)

Advanced Intelligent Systems, EarlyView.
Four decades of retinal vessel segmentation research (1982–2025) are synthesized, spanning classical image processing, machine learning, and deep learning paradigms. A meta‐analysis of 428 studies establishes a unified taxonomy and highlights performance trends, generalization capabilities, and clinical relevance.
Avinash Bansal, Jan Kubíček, Jana Bahrová, Alice Varyšová, Martin Augustýnek, Marek Penhaker, Juraj Timkovič   +6 more
wiley   +1 more source

Automatical sampling with heterogeneous corpora for grammatical error correction

Complex & Intelligent Systems
Thanks to the strong representation capability of the pre-trained language models, supervised grammatical error correction has achieved promising performance.
Shichang Zhu, Jianjian Liu, Ying Li, Zhengtao Yu   +3 more
doaj   +1 more source

Grammatical Error Correction with Neural Reinforcement Learning

CoRR, 2017
We propose a neural encoder-decoder model with reinforcement learning (NRL) for grammatical error correction (GEC). Unlike conventional maximum likelihood estimation (MLE), the model directly optimizes towards an objective that considers a sentence-level, task-specific evaluation metric, avoiding the exposure bias issue in MLE.
Keisuke Sakaguchi, Matt Post, Benjamin Van Durme   +2 more
openaire   +3 more sources

Thai Spelling Correction and Word Normalization on Social Text Using a Two-Stage Pipeline With Neural Contextual Attention

IEEE Access, 2020
Text correction systems (e.g., spell checkers) have been used to improve the quality of computerized text by detecting and correcting errors. However, the task of performing spelling correction and word normalization (text correction) for Thai social ...
Anuruth Lertpiya, Tawunrat Chalothorn, Ekapol Chuangsuwanich   +2 more
doaj   +1 more source

3D‐Printed Shark‐Inspired Soft–Hard Hybrid Underwater Robot With Buoyancy Control and Onboard Vision

Advanced Intelligent Systems, EarlyView.
A fully self‐contained shark‐inspired underwater robot is developed using 3D‐printed soft–hard hybrid structures, servo‐driven propulsion, and pump‐based buoyancy control. The platform achieves three‐dimensional locomotion and onboard vision‐based target tracking, offering a reproducible and accessible framework for biomimetic underwater robot research.
Shotaro Saito, Byeongwook Jo, Minghao Nie, Shoji Takeuchi   +3 more
wiley   +1 more source

Evaluation of Really Good Grammatical Error Correction

Proceedings of the Language Resources and Evaluation Conference
Although rarely stated, in practice, Grammatical Error Correction (GEC) encompasses various models with distinct objectives, ranging from grammatical error detection to improving fluency. Traditional evaluation methods fail to fully capture the full range of system capabilities and objectives.
Östling, Robert, Gillholm, Katarina, Kurfalı, Murathan, Mattson, Marie, Wirén, Mats   +4 more
openaire   +4 more sources