Results 131 to 140 of about 54,367 (305)
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Grammatical Constructions Back to the roots
This volume brings into focus the conceptual roots of the notion 'grammatical construction' as the theoretical entity that constitutes the backbone of Construction Grammar, a unique grammatical model in which grammatical constructions have the status of ...
Boas, Hans C., Fried, Mirjam.
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Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Linguistik OnlineIn German, there is a wide array of figurative designations for persons. They show various degrees of lexical complexity (simple nouns such as Sau, compounds such as Drecksau, collocations such as dreckige Sau) and different semantic domains of origin ...
Claudio Di Meola
doaj
Advanced Science, EarlyView.A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li +14 more
wiley +1 more source
Alternating ditransitives in English: a corpus-based study
, 2009 This thesis is a large-scale investigation of ditransitive constructions and their alternants in English. Typically both constructions involve three participants: participant A transfers an element B to participant C.
Ozon, G.A.
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A Case Study of Cohesion in Academic Texts trough Systemic Functional Linguistics
JALL (Journal of Applied Linguistics and Literacy)This study aims to analyze the use of cohesive devices in undergraduate thesis abstracts by English Department students in Indonesia through the Systemic Functional Linguistics (SFL) approach.
Dwi Putri Lestari, Nurlela Nurlela
doaj +1 more source
Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation
Advanced Science, EarlyView.Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao +10 more
wiley +1 more source
Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
Lexical and Grammatical Cohesion in The Lion King Movie Script
, 2020 The objectives of this research were to identify the types of grammatical and lexical cohesive devices used in The Lion King Movie Script, to describe the grammatical and lexical cohesion devices used in The Lion King Movie Script and to investigate ...
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