Results 231 to 240 of about 7,457 (299)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

open access: yesSmart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin   +10 more
wiley   +1 more source

Capturing Networked Knowledge in a Doctoral Research Training Network: First Findings—The MINDSHIFT Case Study

open access: yesSystems Research and Behavioral Science, EarlyView.
ABSTRACT MINDSHIFT was an EU‐funded doctoral research‐training network on hypertension involving 15 PhD projects across six universities. We present MINDSHIFT as a case study of how a distributed network may develop, structure, and integrate mechanistic knowledge across diverse projects.
Rita Chamoun   +3 more
wiley   +1 more source

Tailoring Microstructure and Hardness in Maraging 300 Steel via 2.4 wt.% Niobium Addition and Controlled Aging Treatments

open access: yessteel research international, EarlyView.
High Nb (2.4 wt.%) addition to Maraging 300 steel drives lattice distortion and nanoscale Nb–Mo‐rich precipitation, confirmed by energy‐dispersive X‐ray spectroscopy mapping (Mo ~5.4 wt.%, Nb ~2.5 wt.%). Nanoindentation reveals strong matrix hardening (H >4.8 GPa) at 480°C aging, while 560°C induces ~1.92 vol.% reverted austenite, enabling tunable ...
Laylla Sharon B. Peixoto   +9 more
wiley   +1 more source

Influence of Surface Roughness and Temperature on Niobium Cathodic Cage Duplex Treatment Applied to VP20TS Steel

open access: yessteel research international, EarlyView.
Niobium cathodic cage duplex treatment is applied to VP20TS steel to evaluate the influence of surface roughness and temperature on coating performance. Results show that higher temperatures promote thicker nitride layers and increased microhardness, while finer surface preparation enhances adhesion and wear resistance, revealing optimal conditions for
Alan Bruno Costa Cardoso   +6 more
wiley   +1 more source

When Time Stands Still: The Destructive Experience of Ambiguous Loss among Mothers of Combat Soldiers

open access: yesSymbolic Interaction, EarlyView.
What happens when stories refuse coherence? This article examines ambiguous loss among mothers of combat soldiers, focusing on how prolonged waiting and uncertainty infiltrate everyday life, eroding sensemaking. Drawing on ethnographic interviews, it explores how mothers experience the contraction of time and space—manifested in suspended routines ...
Shirly Bar‐Lev   +2 more
wiley   +1 more source

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