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open access: yes, 2019
A blog post originally appearing on the Archive Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W.
Grand Challenges at Hope College, Mellon Foundation
core  

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

Predictive toxicity: grand challenges

open access: yesFrontiers in Pharmacology, 2010
OlaviRPelkonen
doaj   +1 more source

Origin Story (May 2018)

open access: yes, 2019
A blog post originally appearing on the Archive Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W.
Grand Challenges at Hope College, Mellon Foundation
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Grand challenges in pediatric stroke. [PDF]

open access: yesFront Stroke, 2023
Ullman N, Licht DJ.
europepmc   +1 more source

Paris Research Presented at NCUR

open access: yes, 2018
A blog post originally appearing on the Paris Stories WordPress site. The original site was created as a component of a funded pathway of the Andrew W. Mellon Foundation Grand Challenges Initiative of Hope College (Nations, Citizens, and Outsiders: Paris
Grand Challenges at Hope College, Mellon Foundation
core  

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Grand Challenges in Bionics

open access: yesFrontiers in Bioengineering and Biotechnology, 2013
Danilo Emilio De Rossi, Michael ePieroni
doaj   +1 more source

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