Environmental psychology as the science of context: grand challenges for the next decade. [PDF]
Front PsycholRuotolo F, Aletta F.
europepmc +1 more source
Grand challenges in molecular cardiology. [PDF]
Front Mol Med, 2022 De Windt LJ.
europepmc +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Grand challenges in heat engines
Frontiers in Thermal Engineering, 2023 Ricardo Novella
doaj +1 more source
Revisiting the grand challenges in oral cancers: advances in biomarkers and treatment strategies. [PDF]
Front Oral HealthColetta RD +3 more
europepmc +1 more source
Grand challenges and living labs: toward achieving the Sustainable Development Goals. [PDF]
Front Public Health, 2023 Molnar A, Lepenies R, Borda A, Pedell S.
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Grand challenges in sex differences in immunology: problems the field must solve before biological sex can guide clinical practice. [PDF]
Front ImmunolFlanagan KL, Kovats S.
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ACS Polymers Au's Grand Challenges in Polymer Science. [PDF]
ACS Polym Au, 2023 Jayaraman A, Klok HA.
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In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source