Results 161 to 170 of about 4,689,119 (260)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

A Case for the Humanities [PDF]

open access: yes
First proposed in 2020 and supported by UCL’s Grand Challenge of Cultural Understanding, the UCL Enquiry on a Case for the Humanities set out to articulate and celebrate the value of the Humanities.
Wilson, James   +7 more
core  

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

Grand Challenges in Obstetrics and Gynecology. [PDF]

open access: yesFront Med (Lausanne), 2022
Yagel S, Cohen SM.
europepmc   +1 more source

Grand Challenges Conference New Directions in Grand Challenges Research

open access: yes, 2016
A presentation on 2016-19 Breaking Through: New Directions in Grand Challenges Research with information on the grant and a Q&A ...
Weldon, Laurel, Froehlich, Peter
core  

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

open access: yesFEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy