Results 31 to 40 of about 2,844,213 (242)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Weighted Grand Herz–Morrey–Lizorkin–Triebel Spaces with Variable Exponents
Journal of Contemporary Mathematical Analysis (Armenian Academy of Sciences)arXiv admin note: text overlap with arXiv:2502 ...
Wang, Shengrong +2 more
openaire +2 more sources
Modular Geometric Properties in Variable Exponent Spaces
, 2022 Much has been written on variable exponent spaces in recent years. Most of the literature deals with the normed space structure of such spaces. However, because of the variability of the exponent, the underlying modular structure of these spaces is ...
Simeon Reich +2 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
University of Dayton Exponent, April 1954 [PDF]
, 1954 Published monthly, usually October through May, in the interest of the students of the University of Dayton. Contents include essays, editorials, poems, plays, histories, and other creative works.https://ecommons.udayton.edu/exponent/1432/thumbnail ...
University of Dayton Exponent
core +1 more source
Duality of Variable Exponent Triebel-Lizorkin and Besov Spaces [PDF]
, 2012 We will prove the duality and reflexivity of variable exponent Triebel-Lizorkin and Besov spaces. It was shown by many authors that variable exponent Triebel-Lizorkin spaces coincide with variable exponent Bessel potential spaces, Sobolev spaces, and ...
Takahiro Noi
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Sobolev embeddings in grand variable Herz-Morrey Besov spaces
Boundary Value ProblemsThis paper develops a comprehensive framework for the study of grand variable Herz-Morrey Besov spaces with variable smoothness and integrability.
Babar Sultan, Amjad Hussain
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source