Results 51 to 60 of about 137,006 (311)

Dynamic compaction of granular materials [PDF]

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2013
An Eulerian hyperbolic multiphase flow model for dynamic and irreversible compaction of granular materials is constructed. The reversible model is first constructed on the basis of the classical Hertz theory. The irreversible model is then derived in accordance with the following two basic principles.
Favrie, N., Gavrilyuk, S.
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A Bounding Surface for Granular Materials

Soils and Foundations, 1987
ABSTRACT A laboratory investigation has been carried out into initial anisotropy and into the effects of continuous principal stress rotation on the undrained behaviour of two granular materials : a natural angular to sub-angular sand and glass ballotini, which comprises spherical grains.
SHIBUYA, S., HIGHT, D.W.
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Methods for Control of Granular Material Attributes [PDF]

, 2023
A granular material is a collection of discrete, solid particles. This substance is ubiquitous in nature and industry, with examples ranging from soils, jointed rocks, foodstuffs, ball bearings, powders, and even asteroids.
Buarque de Macedo, Robert Andrew
core   +1 more source

Aplicação da alvenaria estrutural em sistemas de armazenamento de produtos agrícolas a granel Applying structural masonry for granular material storage systems

Engenharia Agrícola, 2011
O armazenamento de produtos agrícolas cumpre um papel importante no agronegócio. Observa-se uma tendência cada vez maior em se trabalhar com produtos a granel, em grandes volumes.
José F. de A Marques Neto, Maria C. A. T. da Silva   +1 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Study on the stability of particle packing structure based on cells

Frontiers in Physics, 2022
The macroscopic mechanical property and the stability of granular mechanics system are determined by packing structure. Cells play a fundamental role in granular statistical mechanics and thus cells were utilized in this paper to research the packing ...
Yunsong Hua, Yujiao Xin, Hongyang Dai, Hui Yang, Zhipeng Chi, Ran Li, Ran Li   +6 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acoustic emissions during creep under triaxial compression [PDF]

E3S Web of Conferences
Granular materials exhibit time- and rate-dependent behaviour resulting from micromechanical processes at the scale of individual particles. Elastic energy is released during these processes and can be detected as acoustic emissions (AE).
Bock Belinda, Vogt Stefan, Cudmani Roberto   +2 more
doaj   +1 more source