Results 91 to 100 of about 369,640 (388)

CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis

Journal of Neuroinflammation, 2012
BackgroundGranulocytes generally exert protective roles in the central nervous system (CNS), but recent studies suggest that they can be detrimental in experimental autoimmune encephalomyelitis (EAE), the most common model of multiple sclerosis.
M. Roy, J. Richard, Aline Dumas, L. Vallières   +3 more
semanticscholar   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. [PDF]

, 2017
BACKGROUND: Delayed immunologic aging is purported to be a major mechanism through which calorie restriction (CR) exerts its anti-aging effects in non-human species.
Epel, Elissa S, Flynn, James M, Kapahi, Pankaj, Lin, Jue, Melov, Simon, Milush, Jeffrey M, Sinclair, Elizabeth, Tomiyama, A Janet, Verdin, Eric   +8 more
core   +3 more sources

Chemical toxicity of the granulocyte. [PDF]

Environmental Health Perspectives, 1981
The effect of chemicals, including pharmacologic agents, on blood granulocytes, may be considered in terms of the effects on the function of mature cells as well as on their number. In turn, the number of cells can be influenced by chemicals which affect production, destruction or distribution within the blood.
openaire   +2 more sources

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

Advanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang, Su Hyun Jung, Seyong Kwon, Sung Jin Park, Joo H. Kang   +4 more
wiley   +1 more source

Individual quality assessment of autografting by probability estimation for clinical endpoints: a prospective validation study from the European group for blood and marrow transplantation. [PDF]

, 2013
The aim of supportive autografting is to reduce the side effects from stem cell transplantation and avoid procedure-related health disadvantages for patients at the lowest possible cost and resource expenditure.
Campioni, Dc, Cuneo, A, Farge, D, Fiamenghi, C, Fruehauf, S, Hellmann, A, Johnsen, He, Knopińska, W, Lanza, F, Madrigal, A, Milone, G, Mohty, M, Passweg, J, Petriz, J, Quality Assessment of Haematopoietic Stem Cell Grafting Committee of European Blood and Marrow Transplantation Society, Ruuto, T, Spedini, P, Swierkowska-Czeneszew, M, Wahlin, A, Walewski, J   +19 more
core   +1 more source

Orbital granulocytic sarcoma [PDF]

British Journal of Ophthalmology, 1997
Orbital granulocytic sarcoma is a localised tumour composed of cells of myeloid origin. Histological diagnosis can be difficult in patients with poorly differentiated orbital tumours and no evidence of systemic leukaemia. The naphthol AS-D chloracetate esterase (Leder stain) and immunohistochemical stains for lysozyme and MAC387 were used to determine ...
Stockl Fa, Font Rl, Saornil Ma, Miguel N. Burnier, Dolmetsch Am   +4 more
openaire   +3 more sources

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma.

Proceedings of the National Academy of Sciences of the United States of America, 1998
We conducted a Phase I clinical trial investigating the biologic activity of vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor in patients with metastatic melanoma ...
R. Soiffer, T. Lynch, M. Mihm, K. Jung, Catherine Rhuda, J. Schmollinger, F. Hodi, L. Liebster, P. Lam, S. Mentzer, Samuel Singer, K. Tanabe, Cosimi Ab, Rosemary B. Duda, A. Sober, A. Bhan, J. Daley, D. Neuberg, Gareth Parry, J. Rokovich, L. Richards, J. Drayer, A. Berns, S. Clift, L. Cohen, R. Mulligan, G. Dranoff   +26 more
semanticscholar   +1 more source

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma

Advanced Science, EarlyView.
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao, Xiaolei Cheng, Rongbin Lv, Dianshui Sun, Jihua Wang, Runjia Fu, Rumei Gong, Yueying Xiao, Qin Liu, Xiaomei Li   +9 more
wiley   +1 more source

The effect of pegbovigrastim on circulating neutrophil count in dairy cattle : a randomized controlled trial [PDF]

, 2018
Previous research in various species has shown that granulocyte-colony stimulating factor stimulates the production and release of neutrophils from bone marrow.
Bogado Pascottini, Osvaldo Américo, Carrier, J, LeBlanc, SJ, Van Schyndel, SJ   +3 more
core   +1 more source