Results 121 to 130 of about 369,640 (388)

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Pengaruh Escherichia coli dan granulosit terhadap kadar reactive oxygen species secara in vitro

Journal of Biological Researches, 2012
In humans, male genital tract infection has been recognized as one of the causes of infertility. Indicators of the occurrence ofgenital tract infection are the presence of bacteria during semen culture (bacteriospermia) and the finding of leucocyte of ...
Sukarjati M Sukarjati, Doddy M Soebadi, Aucky M Hinting, Sudjarw M Sudjarw   +3 more
doaj   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization

Nature Network Boston, 2011
In sub-Saharan Africa, invasive nontyphoid Salmonella (NTS) infection is a common and often fatal complication of Plasmodium falciparum infection. Induction of heme oxygenase-1 (HO-1) mediates tolerance to the cytotoxic effects of heme during malarial ...
Aubrey J Cunnington, J. de Souza, Michael Walther, Eleanor M. Riley   +3 more
semanticscholar   +1 more source

Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

Advanced Science, EarlyView.
A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao, Chih‐Ying Chen, Ya‐Hui Lin, Wan‐Chi Pan, Chun‐Yi Liang, Hsiu‐Ching Liu, Lo‐Jei Ching, Pei‐Yu Weng, Min‐Ren Chiang, Ru‐Siou Hsu, Tsu‐Chin Chou, I‐Chi Lee, Lun‐De Liao, Li‐An Chu, Shih‐Hwa Chiou, Shang‐Hsiu Hu   +15 more
wiley   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration [PDF]

, 2014
Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated ...
A Tidholm, BD Rose, CC Horn, CL Limebeer, DC Dale, DM Vail, E Portillo, EM Rock, G Jang, GK Ogilvie, GK Ogilvie, GP Chrousos, GR Morrow, H Imamura, Hannah Kenward, IK Vonderen van, J Ito, J Loor, JD Chen, Jonathan Elliott, K Barabas, K Olsson, KL Koch, L Kelland, LA Parker, LA Parker, Ludovic Pelligand, LX Cubeddu, LX Cubeddu, M Boer-Dennert de, M Fredrikson, M Minami, MK Samson, MS Kim, N Percie du Sert, N Percie du Sert, PL Andrews, PL Andrews, PL Andrews, RD Fisher, S Ina, S Robery, SD Caras, T Bloom, V Napadow, VA Puente-Redondo de la, X Yu   +46 more
core   +2 more sources

THE ROLE OF THE GRANULOCYTE AS A SOURCE OF LYSOZYME IN ULCERATIVE COLITIS 1 [PDF]

, 1952
Robert B. Hiatt, Claire G. Engle, C. Flood, Aaron Karush   +3 more
openalex   +1 more source

Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.

Journal of Clinical Investigation, 1986
A purified recombinant human granulocyte-macrophage colony stimulating factor (rH GM-CSF) was a powerful stimulator of mature human eosinophils and neutrophils. The purified rH GM-CSF enhanced the cytotoxic activity of neutrophils and eosinophils against
A. Lopez, D. Williamson, J. Gamble, C. Begley, J. Harlan, S. Klebanoff, A. Waltersdorph, G. Wong, S. Clark, M. Vadas   +9 more
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source