Results 231 to 240 of about 168,890 (312)

The Immunological Correlation With Adenoid Hypertrophy and Allergic Rhinitis in Children

open access: yesiNew Medicine, EarlyView.
The imbalance of Th1/Th2 and Th17/Treg cells in allergen and inflammatory responses might be associated with the development of adenoid hypertrophy, suggesting that allergic rhinitis maybe the risk factor of AH and providing a potential alternative explanation for adenoid hypertrophy pathogenesis.
Yang Song   +4 more
wiley   +1 more source

MMP-9 affects dural cell composition and granulocyte accumulation during neuroinflammation. [PDF]

open access: yesFront Immunol
Shen SH   +8 more
europepmc   +1 more source

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

open access: yesInterdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling   +13 more
wiley   +1 more source

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach   +8 more
wiley   +1 more source

The Immunoregulatory and Hematopoietic Effects of Momelotinib in a Murine Bone Marrow Failure Model

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Momelotinib, a selective small‐molecule inhibitor of JAK1/2 and the bone morphogenic protein receptor kinase activin A receptor type I (ACVR1), exerts its effects by inhibiting the overactivation of the BMP/ACVR1/SMAD signaling pathway. This inhibition reduces hepcidin production in hepatocytes, and reduces inflammation, aberrant cytokine signaling ...
Yue Zhang   +7 more
wiley   +1 more source

Neoadjuvant Chemotherapy With Gemcitabine/Cisplatin/S‐1 for Resectable Biliary Tract Cancer With FDG‐PET‐Positive Lymph Node Metastasis (KHBO1201): A Multicenter Phase II Trial

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Purpose To evaluate the safety and efficacy of neoadjuvant gemcitabine, cisplatin, and S‐1 (GCS) chemotherapy for resectable biliary tract cancer (BTC) and FDG‐PET‐positive lymph nodes in a multicenter phase II study (KHBO1201). Methods Patients with resectable BTC (intrahepatic/extrahepatic bile duct, gallbladder, or ampullary cancers) and ...
Satoshi Ogiso   +9 more
wiley   +1 more source

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