Results 71 to 80 of about 369,640 (388)

Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers

Frontiers in Pharmacology, 2018
Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell
Lisa M. Fleischer, Rachana D. Somaiya, Gregory M. Miller, Gregory M. Miller, Gregory M. Miller   +4 more
doaj   +1 more source

The Value of Immature Granulocyte and Immature Granulocyte/Total Granulocyte Ratio in Predicting the Need for Surgical Treatment in Patients Diagnosed with Intestinal Ileus in the Emergency Department

Genel Tıp Dergisi, 2023
Background/Aims: Although many biomarkers that can predict the need for surgical treatment of patients with intestinal ileus have been investigated, effective, inexpensive, and fast-resulting biomarkers have not been determined. In our study, showing the
Yunsur Çevik, Şeref Kerem Çorbacıoğlu, Meral Yıldırım, Hakan Yaşar, Emine Emektar   +4 more
doaj   +1 more source

Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer

, 1991
Background. Neutropenia and infection are major dose-limiting side effects of chemotherapy. Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating factor (G-CSF) can reduce chemotherapy-related neutropenia in patients ...
J. Crawford, H. Ozer, R. Stoller, David H. Johnson, G. Lyman, I. Tabbara, M. Kris, J. Grous, V. Picozzi, G. Rausch, Roy E. Smith, W. Gradishar, A. Yahanda, M. Vincent, M. Stewart, J. Glaspy   +15 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Granulocytic sarcoma of the skin [PDF]

Canadian Medical Association Journal, 2008
An 89-year-old woman with refractory anemia presented with a painful neck mass that measured 5 cm × 3 cm ([Figure 1][1]A). Her peripheral leukocyte count was (118 × 109/L), with 98% immature blood cells.
PIRISI, Mario, KRENGLI, Marco, VALENTE, Guido   +2 more
openaire   +5 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Normal chemotactic activity of granulocytes obtained by filtration leucapheresis [PDF]

, 1977
The chemotactic activity of granulocytes obtained by the Terumo Filtration Leucapheresis System (F.L.) was examined by the method of Boyden's chamber. The number of cells migrating through the Millipore filter was expressed as the chemotactic activity ...
Kimura, Ikuro, Kitagawa, Nakayuki, Kitajima, Koichi, Koi, Fumikazu, Takahashi, Isao, Toki, Hironobu, Tokioka, Masaaki   +6 more
core   +1 more source

Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan, María A. Piedrabuena, María A. Zarate, Sofía Rodríguez Murúa, Ezequiel I. Surace, Mauricio F. Farez, Marcela P. Fiol, María C. Ysrraelit, Jorge Correale   +8 more
wiley   +1 more source

Comparaison de deux anticoagulants pour la production de l’antigène de Cowdria ruminantium dans une culture de neutrophiles

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1995
L'activité de deux anticoagulants, l'éthylène diamine tétra-acétate (EDTA) et l'héparine, a été comparée sur du sang de chèvres cliniquement infectées par Cowdria ruminantium. Les neutrophiles ont été extraits du sang et mis en culture pour la production
Daniel Nzingu Awa, Edith A. Paxton, K.J. Sumption   +2 more
doaj   +1 more source