Results 41 to 50 of about 116,398 (264)

Aggressive Recurrent Pancreatic Cancer Producing Granulocyte Colony-Stimulating Factor

Case Reports in Gastroenterology, 2020
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein which stimulates the proliferation, differentiation, and functional activation of myeloid hematopoietic cells. G-CSF-producing pancreatic cancer is rare and its prognosis is strikingly poor.
Yoshifumi Morita, Takanori Sakaguchi, Shinya Ida, Ryuta Muraki, Ryo Kitajima, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroe Tsukui, Hiroya Takeuchi   +10 more
doaj   +1 more source

Granulocyte colony‐stimulating factor is not pathogenic in lupus nephritis

Immunity, Inflammation and Disease, 2021
Systemic lupus erythematosus (lupus) is an autoimmune disease characterized by autoantibodies that form immune complexes with self‐antigens, which deposit in various tissues, leading to inflammation and disease.
Timothy A. Gottschalk, Fabien B. Vincent, Alberta Y. Hoi, Margaret L. Hibbs   +3 more
doaj   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

G-CSF Prevents the Progression of Structural Disintegration of White Matter Tracts in Amyotrophic Lateral Sclerosis: A Pilot Trial

, 2011
Background: The hematopoietic protein Granulocyte-colony stimulating factor (G-CSF) has neuroprotective and regenerative properties. The G-CSF receptor is expressed by motoneurons, and G-CSF protects cultured motoneuronal cells from apoptosis.
Tobias Warnecke, Schneider, A, Deppe Michael, Floel, A, Thomas Duning, Harald Kugel, Mohammadi Siawoosh, Katja Kolpatzik, Knecht Stefan, Schiffbauer, H, Wolf Rüdiger Schäbitz, Hagen Schiffbauer, Schäbitz Wolf Rüdiger, Duning Thomas, Kugel Harald, Knecht, S, Warnecke Tobias, Agnes Floel, Kolpatzik, K, Warnecke, T, Floel Agnes, Kugel, H, Schabitz, WR, Deppe, M, Kolpatzik Katja, Armin Schneider, Mohammadi, S, Michael Deppe, Duning, T, Schneider Armin, Stefan Knecht, Siawoosh Mohammadi, Schiffbauer Hagen   +32 more
core   +1 more source

DNA-Encoded Fetal Liver Tyrosine Kinase 3 Ligand and Granulocyte Macrophage-Colony-Stimulating Factor Increase Dendritic Cell Recruitment to the Inoculation Site and Enhance Antigen-Specific CD4+ T Cell Responses Induced by DNA Vaccination of Outbred Animals [PDF]

, 2002
DNA-based immunization is a contemporary strategy for developing vaccines to prevent infectious diseases in animals and humans. Translating the efficacy of DNA immunization demonstrated in murine models to the animal species that represent the actual ...
Timothy V. Baszler, Baszler, Timothy V, Brown, Wendy C, Chris J. Howard, Jayne C. Hope, Wendy C. Brown, Lewin, Harris A., Waithaka Mwangi, Howard, Chris J, Palmer, Guy H, Patrick Caplazi, Abbott, Jeffrey, Mwangi, Waithaka, Hope, Jayne; id_orcid, Baszler, Tim V, Hope, Jayne C, Caplazi, Patrick, Harris A. Lewin, Guy H. Palmer, Jeffrey Abbott, Lewin, Harris A   +20 more
core   +1 more source

Double‐ring sign in granulocyte colony‐stimulating factor‐induced vasculitis

Respirology Case Reports, 2022
Key message If a double‐ring sign is found in contrast‐enhanced computed tomography, this should raise concern not only for Takayasu arteritis, but also for granulocyte colony‐stimulating factor‐induced vasculitis.
Reimi Mizushima, Ryota Kikuchi, Hiroyuki Takoi, Nao Shioiri, Kazutoshi Toriyama, Shinji Abe   +5 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Hematopoietic progenitor cell mobilization for autologous transplantation - a literature review

Revista Brasileira de Hematologia e Hemoterapia, 2016
The use of high-dose chemotherapy with autologous support of hematopoietic progenitor cells is an effective strategy to treat various hematologic neoplasms, such as non-Hodgkin lymphomas and multiple myeloma.
Marco Aurélio Salvino, Jefferson Ruiz
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source