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Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
New England Journal of Medicine, 1992FOUR colony-stimulating factors influence the survival, proliferation, differentiation, and functional activation of myeloid hematopoietic cells: macrophage colony-stimulating factor (M-CSF), granulocyte colony-stimulating factor (G-CSF), granulocytemacrophage colony-stimulating factor (GM-CSF), and interleukin-3 (formerly known as multi-colony ...
Alastair J J Wood +2 more
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Granulocyte and granulocyte-macrophage colony-stimulating factors
Lancet, The, 1993W P Steward
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Granulocyte Colony-Stimulating Factor
Southern Medical Journal, 1993Recombinant human granulocyte colony-stimulating factor (G-CSF) is a nonglycosylated protein produced in Escherichia coli using recombinant DNA technology. G-CSF was first defined in vitro as a relatively selective stimulator of pure granulocyte colonies from normal marrow and as a factor that induces differentiation of leukemic cell lines.
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The Granulocyte-Macrophage Colony-Stimulating Factors
Science, 1985The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages.
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Current Opinion in Hematology, 1995
Hematopoietic growth factors primarily used in patients with acute myelogenous leukemia after chemotherapy could reduce significantly the neutrophil recovery time in all patients. In high-risk acute myelogenous leukemia, trials also reported a reduction in the incidence of documented infections and early mortality rate.
D, Hoelzer, G, Seipelt
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Hematopoietic growth factors primarily used in patients with acute myelogenous leukemia after chemotherapy could reduce significantly the neutrophil recovery time in all patients. In high-risk acute myelogenous leukemia, trials also reported a reduction in the incidence of documented infections and early mortality rate.
D, Hoelzer, G, Seipelt
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Granulocyte-Macrophage Colony-stimulating Factor
Biotherapy, 1990Publisher Summary Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of the four classical colony-stimulating factors discovered in the 1960s following the introduction of semi-solid bone-marrow culture techniques. The human GM-CSF gene is located on chromosome 5 (q25–q31) within 10 kb of the interleukin-3 (IL-3) gene and in the same ...
S, Devereux, D C, Linch
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Granulocyte Colony-Stimulating Factors
2004Granulocyte colony-stimulating factor (G-CSF) is a major regulator of the development of antibacterial neutrophilic granulocytic leukocytes (neutrophils). In keeping with the functions of both G-CSF and neutrophils, the murine molecule was first purified from medium that had bathed the dissected lungs of animals previously treated with a bacterial cell-
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Granulocyte colony stimulating factor.
Methods in enzymology, 1986Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be ...
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