Results 91 to 100 of about 113,926 (280)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Pest categorisation of non‐EU viruses and viroids of Vitis L.

open access: yesEFSA Journal, 2019
Following a request from the EU Commission, the Panel on Plant Health addressed the pest categorisation of the viruses and viroids of Vitis L. determined as being either non‐EU or of undetermined standing in a previous EFSA opinion.
EFSA Panel on Plant Health (EFSA PLH Panel)   +29 more
doaj   +1 more source

Geology of the Tehachapi Mountains, California [PDF]

open access: yes, 1954
The San Joaquin-Sacramento Valley, also known as the Great Valley of California, separates the Coast Ranges on the west from the Sierra Nevada on the east. The southern part of this major physiographic and structural province is about 50 miles in average
Buwalda, John P.
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Evaluation of sanitary status of grapevines in the Czech Republic

open access: yesPlant, Soil and Environment, 2003
A survey was made to evaluate sanitary status of grapevines in the Czech Republic with regard to occurrence of economically important viruses. Propagation material of 109 grapevine clones was tested for presence of Grapevine fanleaf virus, Arabis mosaic ...
P. Komínek, V. Holleinová
doaj   +1 more source

Guide to the Chateau Benoit Collection [PDF]

open access: yes, 2018
This collection is comprised of a large variety of publications, documents, photographs, books, and other materials from Fred and Mary Benoit’s time as owners of Chateau ...
Linfield College Archives
core   +1 more source

Grapevine leafroll-associated virus 3. [PDF]

open access: yes, 2013
Grapevine leafroll disease (GLD) is one of the most important grapevine viral diseases affecting grapevines worldwide. The impact on vine health, crop yield, and quality is difficult to assess due to a high number of variables, but significant economic ...
Adib eRowhani   +14 more
core   +2 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Harmonization and validation of diagnostic protocols for the detection of grapevine viruses covered by phytosanitary rules

open access: yesAdvances in Horticultural Science, 2013
The Italian Ministry of Agriculture funded in 2009 the “ARNADIA” Project, aimed at producing validated reference diagnostic protocols for the control and monitoring of plant pathogens of phytosanitary interest and, among them, grapevine viruses. In this
F. Faggioli   +26 more
doaj   +1 more source

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