Results 61 to 70 of about 21,194 (299)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Drawing Links from Transcriptome to Metabolites: The Evolution of Aroma in the Ripening Berry of Moscato Bianco (Vitis vinifera L.)

Frontiers in Plant Science, 2017
Monoterpenes confer typical floral notes to “Muscat” grapevine varieties and, to a lesser extent, to other aromatic non-Muscat varieties. Previous studies have led to the identification and functional characterization of some enzymes and genes in this ...
Laura Costantini, Christian D. Kappel, Massimiliano Trenti, Juri Battilana, Francesco Emanuelli, Maddalena Sordo, Marco Moretto, Céline Camps, Roberto Larcher, Serge Delrot, Maria S. Grando, Maria S. Grando   +11 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Stability of Ampelometric Characteristics of Vitis vinifera L. cv. 'Syrah' and 'Sauvignon blanc' Leaves: Impact of Within-vineyard Variability and Pruning Method/Bud Load [PDF]

, 2013
Historically, grapevine (Vitis vinifera L.) leaf characterisation has been a driving force in the identification of cultivars. In this study, ampelometric (foliometric) analysis was done on leaf samples collected from hand-pruned, mechanically pruned and
Baranyai, László, Bisztray, György, Bodor, Péter, Bálo, Borbála, Hunter, J, Ladányi, Márta, Strever, Albert   +6 more
core  

Genetic diversity, linkage disequilibrium and power of a large grapevine (Vitis vinifera L) diversity panel newly designed for association studies [PDF]

, 2016
UMR-AGAP Equipe DAVV (Diversité, adaptation et amélioration de la vigne) ; équipe ID (Intégration de Données)International audienceAbstractBackgroundAs for many crops, new high-quality grapevine varieties requiring less pesticide and adapted to climate ...
A Barnaud, A Barnaud, A Coupel-Ledru, A Dereeper, A Doligez, A Doligez, A Doligez, A Fodor, A Fournier-Level, A Fournier-Level, A Negrul, A Rafalski, A Tenesa, Agnès Doligez, AJ Eckert, Alexis Dereeper, AM Casa, AM Vargas, Amandine Launay, Aurélie Bérard, B Gouesnard, B Mangin, BA Loiselle, Brigitte Mangin, C Houel, C Leeuwen van, CS Zhu, D Falush, D Habier, D Lijavetzky, D Zohary, DJ Schoen, E Cadic, E Duchêne, E Karaagac, E Marguerit, EA Thompson, F Emanuelli, F Emanuelli, F Schwander, Frédéric Martins, G Evanno, IPCC, J Battilana, J Chaib, J Li, J Shin, JA Rafalski, Jean-Pierre Péros, JK Pritchard, JM Boursiquot, JM Yu, JM Yu, JM Yu, KA McClure, L Camus-Kulandaivelu, L Costantini, L Cunff Le, L Fernandez, L Grzeskowiak, L Hannah, L Jin, L Riahi, Loïc Le Cunff, M Akkurt, M Dell’Acqua, M Machado, MA Khan, MA Khan, Marie-Christine Le Paslier, MK Aradhya, N Mejia, N Pavy, N Yang, O Jaillon, OIV, P McGovern, Patrice This, PC Sham, Philippe Chatelet, PL Morrell, R Arroyo-Garcia, R Bacilieri, R Bernardo, R Peakall, R Peakall, R Philippe, R Rincent, R Rincent, R Staden, R Velasco, Roberto Bacilieri, S Gerber, S Gurung, S Kim, S Kumar, S Maenhout, S Maenhout, S Myles, S Myles, S Riaz, S Thepot, S Unterseer, S Vezzulli, Sophie Valière, SR Browning, ST Kalinowski, Stéphane D. Nicolas, T Jombart, T Koressaar, T Lacombe, Thierry Lacombe, V Laucou, V Thareau, Valérie Laucou, VE Chhatre, W Hill, W Sannemann, X Gao, XH Huang, XH Huang, Y Bao, Y Huang   +122 more
core   +13 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Non-destructive quantification of key quality characteristics in individual grapevine berries using near-infrared spectroscopy

Frontiers in Plant Science
It is crucial for winegrowers to make informed decisions about the optimum time to harvest the grapes to ensure the production of premium wines. Global warming contributes to decreasing acidity and increasing sugar levels in grapes, resulting in bland ...
Lucie Cornehl, Pascal Gauweiler, Xiaorong Zheng, Julius Krause, Florian Schwander, Reinhard Töpfer, Robin Gruna, Anna Kicherer   +7 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Multivariate classification of prunus dulcis varieties using leaves of nursery plants and near infrared spectroscopy [PDF]

, 2019
The emergence of new almond tree (Prunus dulcis) varieties with agricultural interest is forcing the nursery plant industry to establish quality systems to keep varietal purity in the production stage. The aim of this study is to assess the capability of
Boqué, Ricard, Borraz Martínez, Sergio, Gras Moreu, Anna Maria, Mestre, Mariàngela, Simó Cruanyes, Joan   +4 more
core   +3 more sources