Results 101 to 110 of about 3,583,809 (318)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
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An in-depth statistical analysis of the COVID-19 pandemic’s initial spread in the WHO African region
BMJ Global Health, 2022 Cristina Barroso Hofer +19 more
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On ordered graphs and graph orderings
Discrete Applied Mathematics, 1994 The main result of this paper is: For every oriented graph \(\vec G\) with in-degree for every vertex at least 2 there is no graph \(H\) such that every strong orientation \(\vec H\) of \(H\) contains a copy of \(\vec G\). This disproves a conjecture of \textit{M. Cochand} and \textit{P. Duchet} [Algorithms Comb. 8, 39-46 (1989; Zbl 0698.05055)].
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Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
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Graph traversal and graph transformation
Theoretical Computer Science, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
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Clique graphs of packed graphs
Discrete Mathematics, 1986 Let \(| G|\) be the number of vertices of a graph G and \(\omega\) (G) the number of vertices in the largest clique of G. The clique graph K(G) is the intersection graph of the cliques of G. For all G, \(| K(G)| \leq 2^{| G| -\omega (G)}\) [see \textit{B. Hedman}, Discrete Math.
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Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
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Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
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On the Beta-Number of Forests with Isomorphic Components
Discussiones Mathematicae Graph Theory, 2018 The beta-number, β (G), of a graph G is defined to be either the smallest positive integer n for which there exists an injective function f : V (G) → {0, 1, . . .
Ichishima Rikio +3 more
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