Results 121 to 130 of about 3,368,549 (267)
Homomorphic Preimages of Geometric Cycles
, 2015 A graph G is a homomorphic preimage of another graph H, or equivalently G is H-colorable, if there exists a graph homomorphism from G to H. A classic problem is to characterize the family of homomorphic preimages of a given graph H.
Cockburn, Sally
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Graph Passing in Graph Transformation
, 2012 Graph transformation works under the whole world assumption. Therefore, in realistic systems, both the individual graphs and the set of all such graphs can grow very large. In reactive formalisms such as process algebra, on the other hand, each system is split into smaller components which continually interact; the interactions pass information such as
Ghamarian, A.H., Rensink, Arend
openaire +2 more sources
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Estimating network dimension when the spectrum struggles
Royal Society Open ScienceWhat is the dimension of a network? Here, we view it as the smallest dimension of Euclidean space into which nodes can be embedded so that pairwise distances accurately reflect the connectivity structure.
Peter Grindrod +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Dynamic graph structure and spatio-temporal representations in wind power forecasting
Science and Technology for Energy TransitionWind Power Forecasting (WPF) has gained considerable focus as a crucial aspect of the successful integration and operation of wind power. However, due to the stochastic and unstable nature of wind, it poses a real challenge to effectively analyze the ...
Zang Peng +3 more
doaj +1 more source