Results 71 to 80 of about 3,066,756 (267)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Iterative Algorithm for Finding the Shortest Ways in an Unweighted Undirected Graph

Современные информационные технологии и IT-образование, 2021
There is a problem of finding the shortest paths between two vertices in an unweighted, undirected graph, which is aggravated by the fact that the available algorithms for finding all paths have a complexity of at least .
Valentin Sysoev
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

On covers of graphs by Cayley graphs [PDF]

European Journal of Combinatorics, 2017
We prove that every vertex transitive, planar, 1-ended, graph covers every graph whose balls of radius r are isomorphic to the ball of radius r in G for a sufficiently large r. We ask whether this is a general property of finitely presented Cayley graphs, as well as further related questions.
openaire   +3 more sources

Optimizing an Organized Modularity Measure for Topographic Graph Clustering: a Deterministic Annealing Approach

, 2010
This paper proposes an organized generalization of Newman and Girvan's modularity measure for graph clustering. Optimized via a deterministic annealing scheme, this measure produces topologically ordered graph clusterings that lead to faithful and ...
Becker, Bishop, Blondel, Boulet, Butts, Cerny, Di Battista, Duch, Eades, Fabrice Rossi, Fabrikant, Fortunato, Fruchterman, Golub, Graepel, Graepel, Guimera, Herman, Hofmann, Jaakkola, Knuth, Lee, Lehmann, Nathalie Villa-Vialaneix, Newman, Newman, Newman, Newman, Newman, Noack, Noack, Purchase, Reichardt, Rose, Schaeffer, Schölkopf, Vesanto, von Luxburg, Ware, Wasserman, Watts, Yen, Zachary   +42 more
core   +3 more sources

Graphical Analysis of A Marine Plankton Community Reveals Spatial, Temporal, and Niche Structure of Sub-Communities

Frontiers in Marine Science, 2022
Species-rich communities are structured by environmental filtering and a multitude of associations including trophic, mutualistic, and antagonistic relationships.
Joseph T. Siddons, Andrew J. Irwin, Zoe V. Finkel   +2 more
doaj   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Graph Powers and Graph Homomorphisms [PDF]

The Electronic Journal of Combinatorics, 2010
In this paper, we investigate some basic properties of fractional powers. In this regard, we show that for any non-bipartite graph $G$ and positive rational numbers ${2r+1\over 2s+1} < {2p+1\over 2q+1}$, we have $G^{2r+1\over 2s+1} < G^{2p+1\over 2q+1}$. Next, we study the power thickness of $G$, that is, the supremum of rational numbers ${2r+
Ali Taherkhani, Hossein Hajiabolhassan
openaire   +3 more sources

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source