Results 191 to 200 of about 245,907 (259)

DiNovo enables high-coverage and high-confidence de novo peptide sequencing via mirror proteases and deep learning. [PDF]

Nat Commun
Cao Z, Peng X, Zhang D, Zhou P, Kang L, Chi H, Wu R, Cheng Z, Zhang Y, Dai J, Li Y, Yao L, Li X, He Y, Yang J, Wang H, Xu P, Fu Y.   +17 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Fine-tuned large language models with structured prompts enable efficient construction of lung cancer knowledge graphs. [PDF]

Sci Rep
Zhou C, Gong Q, Luan H, Zhan W, Zhu J, Zhang Q.   +5 more
europepmc   +1 more source

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Computing double-pushout graph transformation rules and atom-to-atom maps from KEGG RCLASS data. [PDF]

Algorithms Mol Biol
Beier N, Gatter T, Andersen JL, Stadler PF.   +3 more
europepmc   +1 more source

An Intelligent Multi-Task Supply Chain Model Based on Bio-Inspired Networks. [PDF]

Biomimetics (Basel)
Khaleghi M, Sheykhivand S, Khaleghi N, Danishvar S.   +3 more
europepmc   +1 more source

H-SPAR DB: human spaceflight platform for analysis and research-an integrative omics database for space health. [PDF]

Database (Oxford)
Tomazou M, Bourdakou MM, Nicolaidou E, Georgiou G, Savva K, Athieniti E, Menelaou S, Afxenti S, Spyrou GM.   +8 more
europepmc   +1 more source

Strain-level metagenomic profiling using pangenome graphs with PanTax. [PDF]

Genome Res
Zhang W, Liu Y, Li G, Xu J, Chen E, Schönhuth A, Luo X.   +6 more
europepmc   +1 more source