Results 41 to 50 of about 833,220 (275)
A Compendium of Chemical Class and Use Type Open Access Databases
Data, 2020 With an ever-increasing production and registration of chemical substances, obtaining reliable and up to date information on their use types (UT) and chemical class (CC) is of crucial importance.
Niklas Heinemann +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
IEEE Access, 2020 Although source code programs are commonly written as textual information, they enclose syntactic and semantic information that is usually represented as graphs.
Oscar Rodriguez-Prieto +2 more
doaj +1 more source
Statistical data mining for symbol associations in genomic databases
, 2013 A methodology is proposed to automatically detect significant symbol associations in genomic databases. A new statistical test is proposed to assess the significance of a group of symbols when found in several genesets of a given database.
Fournié, Jean-Jacques +2 more
core +3 more sources
Introduction to Graph Databases
, 2014 The use of graphs in analytic environments is getting more and more widespread, with applications in many different environments like social network analysis, fraud detection, industrial management, knowledge analysis, etc. Graph databases are one important solution to consider in the management of large datasets.
Larriba Pey, Josep +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Graphulo Implementation of Server-Side Sparse Matrix Multiply in the Accumulo Database
, 2015 The Apache Accumulo database excels at distributed storage and indexing and is ideally suited for storing graph data. Many big data analytics compute on graph data and persist their results back to the database.
Fuchs, Adam +3 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Working with Legacy Relational Data in A Graph-Based World
International Journal of Population Data Science, 2020 The Next Generation Linkage Management System (NGLMS) was designed around keeping all data in a graph database. However, this constraint, while easily achievable for greenfield projects and/or new data linkage units, may not be easily met where legacy ...
James Farrow
doaj +1 more source