Results 61 to 70 of about 272,337 (306)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Extending Graph-Based Process Discovery for Hierarchical Block Detection and Incomplete Concurrent Relationship Handling

IEEE Access, 2023
The flow of business process activities in an organization can run simply in the form of sequential or complex in the form of choice and parallel. In the discovery process, parallel conditions can be deduced from the concurrent flows between activities ...
Indra Waspada, Riyanarto Sarno, Endang Siti Astuti, Hanung Nindito Prasetyo, Raden Budiraharjo   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Graph Pattern Matching: From Intractable to Polynomial Time [PDF]

, 2010
Graph pattern matching is typically defined in terms of sub-graph isomorphism, which makes it an np-complete problem. Moreover, it requires bijective functions, which are often too restrictive to characterize patterns in emerging applications. We propose
Li, Jianzhong, Tang, Nan, Ma, Shuai, Fan, Wenfei; id_orcid, Wu, Yunpeng, Wu, Yinghui   +5 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Distributed Graph Simulation: Impossibility and Possibility [PDF]

, 2014
This paper studies fundamental problems for distributed graph simulation. Given a pattern query Q and a graph G that is fragmented and distributed, a graph simulation algorithm A is to compute the matches Q(G) of Q in G.
Wang, Xin, Fan, Wenfei; id_orcid, Wu, Yinghui, Deng, Dong   +3 more
core  

SPG: Structure-Private Graph Database via SqueezePIR [PDF]

, 2023
Many relational data in our daily life are represented as graphs, making graph application an important workload. Because of the large scale of graph datasets, moving graph data to the cloud becomes a popular option.
Jilan Lin, Lin, Jilan, Ahmad, Ishtiyaque, Gupta, Trinabh, Xie, Yuan, Trinabh Gupta, Tu, Fengbin, Ling Liang, Ishtiyaque Ahmad, Ding, Yufei, Liang, Ling, Yuan Xie, Qu, Zheng, Zheng Qu, Yufei Ding, Fengbin Tu   +15 more
core   +1 more source

Anatomy of a Data Science Software Toolkit That Uses Machine Learning to Aid ‘Bench-to-Bedside’ Medical Research—With Essential Concepts of Data Mining and Analysis Explained

Applied Sciences, 2021
Data science and machine learning are buzzwords of the early 21st century. Now pervasive through human civilization, how do these concepts translate to use by researchers and clinicians in the life-science and medical field?
László Beinrohr, Eszter Kail, Péter Piros, Erzsébet Tóth, Rita Fleiner, Krasimir Kolev   +5 more
doaj   +1 more source