Results 71 to 80 of about 5,202,836 (295)

SustainGraph: A knowledge graph for tracking the progress and the interlinking among the sustainable development goals’ targets

Frontiers in Environmental Science, 2022
The development of solutions to manage or mitigate climate change impacts is very challenging, given the complexity and dynamicity of the socio-environmental and socio-ecological systems that have to be modeled and analyzed, and the need to include ...
Eleni Fotopoulou, Ioanna Mandilara, Anastasios Zafeiropoulos, Chrysi Laspidou, Giannis Adamos, Phoebe Koundouri, Phoebe Koundouri, Phoebe Koundouri, Phoebe Koundouri, Symeon Papavassiliou   +9 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A graph database for persistent identifiers

, 2019
The Handle Software manages references to resources of information. However, it does not support a search functionality. A prior implementation with Elasticsearch could not efficiently capture the complex structure of our dataset, especially the relationships between handles.
Doan, Triet, Bingert, Sven, Wiese, Lena, Yahyapour, Ramin, Jäschke, Robert, Weidlich, Matthias   +5 more
openaire   +4 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Graph-based implicit knowledge discovery from architecture change logs [PDF]

, 2012
Service architectures continuously evolve as a consequence of frequent business and technical change cycles. Architecture change log data represents a source of evolution-centric information in terms of intent, scope and operationalisation to ...
Pooyan Jamshidi (5276344), Aakash, Ahmad, Aakash Ahmad, Ahmad, Aakash, Claus Pahl (12588787), Pahl, Claus, Muteer Arshad, Jamshidi, Pooyan, Pooyan Jamshidi, Arshad, Muteer, Claus Pahl, Muteer Arshad (12620287), Aakash Ahmad (5022314)   +12 more
core   +2 more sources

Graph Neural Networks on Graph Databases

CoRR
Training graph neural networks on large datasets has long been a challenge. Traditional approaches include efficiently representing the whole graph in-memory, designing parameter efficient and sampling-based models, and graph partitioning in a distributed setup. Separately, graph databases with native graph storage and query engines have been developed,
Dmytro Lopushanskyy, Borun Shi
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

EpiGeNet : A graph database of interdependencies between genetic and epigenetic events in colorectal cancer [PDF]

, 2017
The development of colorectal cancer (CRC)—the third most common cancer type—has been associated with deregulations of cellular mechanisms stimulated by both genetic and epigenetic events.
Balaur, I., Lysenko, A., Saqi, M., Ruskin, H. J., Rawlings, C. J., Mazein, A., Barat, A., Auffray, C.   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Total Semirelib Graph [PDF]

, 2013
In this paper, the concept of Total semirelib graph of a planar graph is introduced. Authors present a characterization of those graphs whose total semirelib graphs are planar, outer planar, Eulerian, hamiltonian with crossing number ...
Prasad, Manjunath, Venkanagouda M Goudar, Goudar, Venkanagouda, Manjunath Prasad K B   +3 more
core   +1 more source