Results 81 to 90 of about 272,337 (306)
, 2015 This project will review the new technology of graph databases. Graph databases, which model data using nodes and relationships, utilize a different paradigm than the rows and columns of relational databases. The main goals of this project are to provide
Dovgin, George
core +1 more source
Graph Neural Networks on Graph Databases
CoRRTraining graph neural networks on large datasets has long been a challenge. Traditional approaches include efficiently representing the whole graph in-memory, designing parameter efficient and sampling-based models, and graph partitioning in a distributed setup. Separately, graph databases with native graph storage and query engines have been developed,
Dmytro Lopushanskyy, Borun Shi
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Benchmarking Database Systems for Graph Pattern Matching [PDF]
, 2014 In graph pattern matching the task is to find inside a given graph some specific smaller graph, called pattern. One way of solving this problem is to express it in the query language of a database system.
Skritek, Sebastian +7 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A study on database conceptual modelling: From Entity-Relationship Diagrams to Graph Database Schema [PDF]
, 2022 non
SINGH, HARJOT
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Converting relational to graph databases [PDF]
, 2013 "Graph Database Management Systems provide an effective and efficient solution to data storage in current scenarios where data are more and more connected, graph models are widely used, and systems need to scale to large data sets. In this framework, the
DE VIRGILIO, ROBERTO +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Graph Data Model for CityGML Utility Network ADE: A Case Study on Water Utilities
ISPRS International Journal of Geo-InformationModelling connectivity in utility networks is essential for operational management, maintenance planning, and resilience analysis. The CityGML Utility Network Application Domain Extension (UNADE) provides a detailed conceptual framework for representing ...
Ensiyeh Javaherian Pour +4 more
doaj +1 more source