Results 91 to 100 of about 3,576,657 (341)
, 2007 Wittkop T, Baumbach J, Lobo FP, Rahmann S. Large scale clustering of protein sequences with FORCE - a layout based heuristic for weighted cluster editing. BMC Bioinformatics.
Wittkop, Tobias +11 more
core +1 more source
Graph Neural Networks on Graph Databases
CoRRTraining graph neural networks on large datasets has long been a challenge. Traditional approaches include efficiently representing the whole graph in-memory, designing parameter efficient and sampling-based models, and graph partitioning in a distributed setup. Separately, graph databases with native graph storage and query engines have been developed,
Dmytro Lopushanskyy, Borun Shi
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Declarative graph querying in practice and theory
, 2017 With the recent resurgence of interest in graph data man- agement, there has been a flurry of research on the design and engineering of graph query languages.
Orlando, Salvatore +8 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
G-CORE a core for future graph query languages
, 2018 We report on a community effort between industry and academia to shape the future of graph query languages. We argue that existing graph database management systems should consider supporting a query language with two key characteristics.
Gutierrez, Claudio +15 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Graph Data Model for CityGML Utility Network ADE: A Case Study on Water Utilities
ISPRS International Journal of Geo-InformationModelling connectivity in utility networks is essential for operational management, maintenance planning, and resilience analysis. The CityGML Utility Network Application Domain Extension (UNADE) provides a detailed conceptual framework for representing ...
Ensiyeh Javaherian Pour +4 more
doaj +1 more source
Knowledge and agent-based system for decentralised scheduling in manufacturing
Cogent Engineering, 2019 The aim of the research paper is to develop algorithms for manufacturers’ agents that would allow them to sequence their own operation plans and to develop a multi-agent infrastructure to allow operation pair agents to cooperatively adjust the timing of ...
Salman Saeidlou +2 more
doaj +1 more source