Results 111 to 120 of about 3,576,657 (341)

Graph Pattern Matching: From Intractable to Polynomial Time

, 2010
Graph pattern matching is typically defined in terms of sub-graph isomorphism, which makes it an np-complete problem. Moreover, it requires bijective functions, which are often too restrictive to characterize patterns in emerging applications. We propose
Li, Jianzhong, Tang, Nan, Ma, Shuai, Fan, Wenfei; id_orcid, Wu, Yunpeng, Wu, Yinghui   +5 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Distributed Graph Simulation: Impossibility and Possibility

, 2014
This paper studies fundamental problems for distributed graph simulation. Given a pattern query Q and a graph G that is fragmented and distributed, a graph simulation algorithm A is to compute the matches Q(G) of Q in G.
Wang, Xin, Fan, Wenfei; id_orcid, Wu, Yinghui, Deng, Dong   +3 more
core  

Graph Database for Collaborative Communities [PDF]

, 2011
Data manipulated in an enterprise context are structured data as well as unstructured data such as emails, documents, and social networks. Graphs are a natural way of representing and modeling such data (structured, semistructured, and unstructured ones)
Rania Soussi, Marie-Aude Aufaure, Hajer Baazaoui, Baazaoui, Hajer, Soussi, Rania, Aufaure, Marie-Aude   +5 more
core   +1 more source

SPG: Structure-Private Graph Database via SqueezePIR

, 2023
Many relational data in our daily life are represented as graphs, making graph application an important workload. Because of the large scale of graph datasets, moving graph data to the cloud becomes a popular option.
Jilan Lin, Lin, Jilan, Ahmad, Ishtiyaque, Gupta, Trinabh, Xie, Yuan, Trinabh Gupta, Tu, Fengbin, Ling Liang, Ishtiyaque Ahmad, Ding, Yufei, Liang, Ling, Yuan Xie, Qu, Zheng, Zheng Qu, Yufei Ding, Fengbin Tu   +15 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Node Classification of Network Threats Leveraging Graph-Based Characterizations Using Memgraph

Computers
This research leverages Memgraph, an open-source graph database, to analyze graph-based network data and apply Graph Neural Networks (GNNs) for a detailed classification of cyberattack tactics categorized by the MITRE ATT&CK framework.
Sadaf Charkhabi, Peyman Samimi, Sikha S. Bagui, Dustin Mink, Subhash C. Bagui   +4 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Temporal Graph Analysis using Gradoop

, 2019
The temporal analysis of evolving graphs is an important requirement in many domains but hardly supported in current graph database and graph processing systems.
Thor, Andreas, Rost, Christopher, Rahm, Erhard   +2 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source