Results 211 to 220 of about 1,586,831 (297)

Elucidating and exploring specialised plant metabolism through a pangenomic and pantranscriptomic lens. [PDF]

Plant J
Choudhary N, Natarajan S, Morweiser C, Grünig N, Hagedorn M, Franke J, Pucker B.   +6 more
europepmc   +1 more source

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

Advanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source

KG-DFI: A Prediction of Drug-Food Interactions Based on Knowledge Graph Embedding. [PDF]

Comput Struct Biotechnol J
Kang M, Lee MJ, Yoo S.
europepmc   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

Mechanism-aware and safety-validated AI for drug repurposing: a critical review and translational pharmacology framework. [PDF]

Front Pharmacol
Hazra M, Anandaram H.
europepmc   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

AResKGLM: a graph-grounded language-model framework for interpretable multi-hop antimicrobial resistance reasoning. [PDF]

Brief Bioinform
Ren J, Yang Z, Liu W, Tat Alexander Ng M.   +3 more
europepmc   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Sampling a trillion-sized GDB-20 database of drug-like molecules by generative artificial intelligence.

Digit Discov
Buehler Y, Javor S, Reymond JL.
europepmc   +1 more source

CRISPR-Cas immune repertoires as an ecological record of bacterial interactions with mobile genetic elements in the human gut. [PDF]

Gut Microbes
Avershina E, Birkeland EE, Bucher-Johannessen C, Rounge TB.   +3 more
europepmc   +1 more source