Results 241 to 250 of about 117,917 (289)

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

StarPepWeb: an integrative, graph-based resource for bioactive peptides. [PDF]

Bioinform Adv
López C, Cárdenas R, Aguilera-Mendoza L, Agüero-Chapin G, Martínez-Rios F, García-Jacas CR, Pérez-Pérez N, Marrero-Ponce Y.   +7 more
europepmc   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

The IGVF catalog-from genetic variation to function. [PDF]

Nucleic Acids Res
Li D, Liu S, Assis PR, Li M, Dong S, Whaling I, Jolanki O, Kagda M, Zhang W, Macias-Velasco JF, Liu T, Cody S, Antonacci-Fulton L, Huang Y, Liu J, Montgomery MT, Zeiberg D, Jain S, Pejaver V, Bergquist T, Chen Y, Radivojac P, Gersbach CA, Sherpa RN, Castro CP, Boyle AP, Starita LM, Fowler DM, Ahituv N, Dey KK, Majoros WH, Reddy TE, Craven M, Sinha R, Sverchkov Y, Cai X, Nzima MZ, Calderwood MA, Rozowsky J, Gerstein M, Ma J, Yue F, Cherry JM, Love MI, Engreitz JM, Hitz BC, Wang T.   +46 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Transfer learning from custom-tailored virtual molecular databases to real-world organic photosensitizers for catalytic activity prediction. [PDF]

Commun Chem
Noto N, Nagano T, Fujinami M, Kojima R, Saito S.   +4 more
europepmc   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

A graph-based approach to variant description extraction from sequences. [PDF]

NAR Genom Bioinform
Santcroos MA, Kosters WA, Lefter M, Laros JFJ, Vis JK.   +4 more
europepmc   +1 more source

Deep learning model of post-translational modification regulating liquid-liquid phase separation. [PDF]

Commun Chem
Hong X, Lv J, Li Z, Zhu J, Li J, Rahman MU, Wei T, Mu J, Chen HF.   +8 more
europepmc   +1 more source

Advancing Drug-Drug Interaction Prediction with Biomimetic Improvements: Leveraging the Latest Artificial Intelligence Techniques to Guide Researchers in the Field. [PDF]

Biomimetics (Basel)
Marqas RB, Simó Z, Mousa A, Özyurt F, Iantovics LB.   +4 more
europepmc   +1 more source