Results 41 to 50 of about 117,917 (289)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Integration of Relational and Graph Databases Functionally
Foundations of Computing and Decision Sciences, 2019 In today’s multi-model database world there is an effort to integrate databases expressed in different data models. The aim of the article is to show possibilities of integration of relational and graph databases with the help of a functional data model ...
Pokorný Jaroslav
doaj +1 more source
AN EMPIRICAL COMPARISON OF NEO4J AND TIGERGRAPH DATABASES FOR NETWORK CENTRALITY
Science Journal of University of Zakho, 2023 Graph databases have recently gained a lot of attention in areas where the relationships between data and the data itself are equally important, like the semantic web, social networks, and biological networks.
Bahzad Chicho +1 more
doaj +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Using SPARQL to access Linked Open Data
The Programming Historian, 2015 This lesson explains why many cultural institutions are adopting graph databases, and how researchers can access these data though the query language called SPARQL.
Matthew Lincoln
doaj
The Use of Graph Databases for Artificial Neural Networks
Journal of Advanced Research in Natural and Applied Sciences, 2021 Storing and using trained artificial neural network (ANN) models face technical difficulties. These models are usually stored as files and cannot be run directly. An artificial neural network can be structurally expressed as a graph.
Ahmet Cumhur Kınacı +1 more
doaj +1 more source
Updating graph databases with Cypher [PDF]
Proceedings of the VLDB Endowment, 2019 The paper describes the present and the future of graph updates in Cypher, the language of the Neo4j property graph database and several other products. Update features include those with clear analogs in relational databases, as well as those that do not correspond to any relational operators.
Green, Alastair +8 more
openaire +3 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source